Steinke, M., Zunhammer, F., Chatzopoulou, E. I., Teller, H., Schütze, K., Walles, H., Rädler, J.O. and Grüttner, C.: Rapid Analysis of Cell–Nanoparticle Interactions using Single-Cell Raman Trapping Microscopy. DOI: 10.1002/anie.201713151
2017
Belka J, Weigel T, Berninger AK, Kurth DG, Nickel J: Growth and Differentiation of Myoblastic Precursor Cells on Thin Films of Metallo-Supramolecular Coordination Polyelectrolyte (MEPE). In: Advanced Materials Interfaces. vol. 4; 2017.
Confalonieri D, La Marca M, van Dongen EMWM, Walles H, Ehlicke F: An Injectable Recombinant Collagen I Peptide-Based Macroporous Microcarrier Allows Superior Expansion of C2C12 and Human Bone Marrow-Derived Mesenchymal Stromal Cells and Supports Deposition of Mineralized Matrix. In: Tissue Eng Part A. 2017: 12.
Christ B FC, Cubukova A, Walles H, Dembski S, Metzger M: Screening applications to test cellular fitness in Transwell(r) models after nanoparticle treatment. In: Methods in Molecular Biology. vol. 1601; 2017: 111-122.
Kimpton LS, Schwab A, Ehlicke F, Waters SL, Please CP, Whiteley JP, Byrne HM: A mathematical model for cell infiltration and proliferation in a chondral defect. In: Math Biosci. vol. 292; 2017: 46-56.
Lagler C, El-Mesery M, Kubler AC, Muller-Richter UDA, Stuhmer T, Nickel J, Muller TD, Wajant H, Seher A: The anti-myeloma activity of bone morphogenetic protein 2 predominantly relies on the induction of growth arrest and is apoptosis-independent. In: PLoS One. vol. 12, 2017/10/14 edn; 2017: e0185720
Nickel J, Ten Dijke P, Mueller TD: TGF-beta family co-receptor function and signaling. In: Acta Biochim Biophys Sin (Shanghai). 2018/01/03 edn; 2017.
Pawelec KM, Confalonieri D, Ehlicke F, van Boxtel HA, Walles H, Kluijtmans SGJM: Osteogenesis and mineralization of mesenchymal stem cells in collagen type I-based recombinant peptide scaffolds. In: J Biomed Mater Res A. vol. 105A, 29 March 2017 edn; 2017: 11.
Schürlein S, Al Hijailan R, Weigel T, Kadari A, Rücker C, Edenhofer F, Walles H, Hansmann J: Generation of a Human Cardiac Patch Based on a Reendothelialized Biological Scaffold (BioVaSc). In: Advanced Biosystems. vol. 1; 2017: n/a-n/a.
Tabisz B, Schmitz W, Schmitz M, Luehmann T, Heusler E, Rybak JC, Meinel L, Fiebig JE, Mueller TD, Nickel J: Site-Directed Immobilization of BMP-2: Two Approaches for the Production of Innovative Osteoinductive Scaffolds. In: Biomacromolecules. vol. 18, 2017/02/18 edn; 2017: 695-708.
2016
Antje Appelt-Menzel and Ivo Schwedhelm FK, Alevtina Cubukova, Frank Edenhofer, Heike Walles, Jan Hansmann: Evaluation of various bioreactor process systems for the production of induced pluripotent stem cells. In: Journal of Translational Science. 2016.
Appelt-Menzel A NW, Cubukova A, Wilhelm A,Günther K, Edenhofer F, Piontek J, Krause G, Stüber T, Walles H, Metzger M: Establishment of a human blood-brain barrier co-culture model mimicking the neurovascular unit using induced pluripotent and multipotent stem cells. In: Stem Cell Reports. vol. in revision; 2016.
Brendtke R, Wiehl M, Sening W, Groeber F, Schwarz T, Walles W, Hansmann J: Feasibility Study on a Microwave-Based Sensor for Measuring Hydration Level Using Human Skin Models. In: PlosONE. 2016.
Fecher D, Hofmann E, Buck A, Bundschuh R, Nietzer S, Dandekar G, Walles T, Walles H, Luckerath K, Steinke M: Human Organotypic Lung Tumor Models: Suitable For Preclinical 18F-FDG PET-Imaging. In: PLoS One. vol. 11; 2016: e0160282.
Göttlich C ML, Kunz M, Schmitt F, Walles H, Walles T, Dandekar T, Dandekar G, Nietzer SL: A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds. In: J Vis Exp. 2016: e53885.
Groeber F, Engelhardt L, Lange J, Kurdyn S, Schmid FF, Rücker C, Mielke S, Walles H, Hansmann J: A first vascularized skin equivalent for as an alternative to animal experimentation. In: ALTEX. 2016.
Haider D, Gilbert DF, Malhotra D, Limmer A, Engelhardt H, Amtmann A, Hansmann J, Hübner H, Buchholz R, Friedrich O et al: Measuring average rheological quantities of cell monolayers in the linear viscoelastic regime. In: Rheologica Acta. 2016.
Jannasch M, Weigel T, Engelhardt L, Wiezoreck J, Gaetzner S, Walles H, Schmitz T, Hansmann J: In vitro chemotaxis and tissue remodeling assays quantitatively characterize foreign body reaction. In: ALTEX. 2016.
Katharina Gunther and Antje Appelt-Menzel CKK, Heike Walles, Marco Metzger and Frank Edenhofer: Rapid Monolayer Neural Induction of induced Pluripotent Stem Cells YieldsStably Proliferating Neural Stem Cells. In: Journal of Stem Cell Research & Therapy. 2016.
Kilian T, Fidler F, Kasten A, Nietzer S, Landgraf V, Weiss K, Walles H, Westphal F, Hackenberg S, Gruttner C et al: Stem cell labeling with iron oxide nanoparticles: impact of 3D culture on cell labeling maintenance. In: Nanomedicine (Lond). 2016.
Lotz C, Schmid FF, Rossi A, Kurdyn S, Kampik D, De Wever B, Walles H, Groeber FK: Alternative methods for the replacement of eye irritation testing. In: ALTEX. vol. 33; 2016: 55-67.
Nietzer S, Baur F, Sieber S, Hansmann J, Schwarz T, Stoffer C, Häfner H, Gasser M, Waaga-Gasser AM, Walles H et al: Mimicking metastases including tumor stroma: a new technique to generate a 3D colorectal cancer model based on a biological decellularized intestinal scaffold. In: Tissue Engineering, Part C: Methods. 03.05.2016 edn; 2016.
Pers YM, Rackwitz L, Ferreira R, Pullig O, Delfour C, Barry F, Sensebe L, Casteilla L, Fleury S, Bourin P et al: Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial. In: Stem Cells Transl Med. vol. 5; 2016: 847-856.
Rosenbaum C, Schick MA, Wollborn J, Heider A, Scholz CJ, Cecil A, Niesler B, Hirrlinger J, Walles H, Metzger M: Activation of Myenteric Glia during Acute Inflammation In Vitro and In Vivo. In: PLoS One. vol. 11, 2016/03/11 edn; 2016: e0151335.
Rossi A, L. W, K.H. H, Walles H, J. G: Isotropic versus bipolar functionalized biomimetic artificial basement membranes and their evaluation in long term human cell co-culture. In: Advanced Healthcare Materials. 2016.
Rücker C, Kirch H, Pullig O, Walles H: Strategies and First Advances in the Development of Prevascularized Bone Implants. In: Current Molecular Biology Reports. 2016: 1-9.
Schuerlein S, Schwarz T, Krziminski S, Gatzner S, Hoppensack A, Schwedhelm I, Schweinlin M, Walles H, Hansmann J: A versatile modular bioreactor platform for Tissue Engineering. In: Biotechnol J. 2016.
Schweinlin M, Rossi A, Lodes N, Lotz C, Hackenberg S, Steinke M, Walles H, Groeber F: Human barrier models for the in vitro assessment of drug delivery. In: Drug Deliv Transl Res. 2016.
Suliman S, Mustafa K, Krueger A, Steinmuller-Nethl D, Finne-Wistrand A, Osdal T, Hamza AO, Sun Y, Parajuli H, Waag T et al: Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes. In: Biomaterials. vol. 95, 2016/04/25 edn; 2016: 11-21.
Suliman S, Sun Y, Pedersen TO, Xue Y, Nickel J, Waag T, Finne-Wistrand A, Steinmuller-Nethl D, Krueger A, Costea DE et al: In Vivo Host Response and Degradation of Copolymer Scaffolds Functionalized with Nanodiamonds and Bone Morphogenetic Protein 2. In: Adv Healthc Mater. vol. 5, 2016/02/09 edn; 2016: 730-742.
Szczerba W, Zukrowski J, Przybylski M, Sikora M, Safonova O, Shmeliov A, Nicolosi V, Schneider M, Granath T, Oppmann M et al: Pushing up the magnetisation values for iron oxide nanoparticles via zinc doping: X-ray studies on the particle's sub-nano structure of different synthesis routes. In: Physical Chemistry Chemical Physics. vol. 18: The Royal Society of Chemistry; 2016: 25221-25229.
2015
Appelt-Menzel A, Rossi A, Kurdyn S, Walles H, Groeber F: Generation of a three-dimensional full thickness skin equivalent and automated wounding. In: JoVE. vol. J Vis Exp. 2015 Feb 26;(96). doi: 10.3791/52576. PMID: 25741763 2015.
Baleeiro RB SM, Rietscher R, Diedrich A,Czaplewska JA, Metzger M, Lehr CM Scherließ R, Hanefeld H, Gottschaldt M, Walden P: Nanoparticle-based mucosal vaccines targeting tumor associated antigens to human dendritic cells. In: Journal of Biomedical nanotechnology. vol. 12; 2015: 1527 - 1543.
Belka J, Weigel T, Berninger AK, Kurth D, Nickel J: Growth and Differentiation of Myoblastic Precursor Cells on Thin Films of Metallo-Supramolecular Coordination Polyelectrolyte (MEPE). In: ACS Applied Materials & Interfaces vol. submitted; 2015.
Brendtke R: Von der Entwicklung bis zur Zertifizierung. In: MEDengineering. 2015: 50-51.
Brendtke R, Wiehl M, Walles H, Hansmann J: Personalized medicine and health monitoring with focus on hydration to improve healthcare systems in context of demographic changes. In: British Journal of Health Informatics and Monitoring. vol. 2; 2015: 11-30.
Fidler F, Steinke M, Kraupner A, Grüttner C, Hiller K, Briel A, Westphal F, Walles H, Jakob P: Stem Cell Vitality Assessment Using Magnetic Particle Spectroscopy. In: IEEE Transactions on Magnetics. vol. 51; 2015.
Hinderer S, Shena N, Ringuette LJ, Hansmann J, Reinhardt DP, Brucker SY, Davis EC, Schenke-Layland K: In vitro elastogenesis: instructing human vascular smooth muscle cells to generate an elastic fiber-containing extracellular matrix scaffold. In: Biomed Mater. vol. 10; 2015: 034102.
Jannasch M, Groeber F, Brattig NW, Unger C, Walles H, Hansmann J: Development and application of three-dimensional skin equivalents for the investigation of percutaneous worm invasion. In: Exp Parasitol. vol. 150; 2015: 22-30.
Klammert U, Mueller TD, Hellmann TV, Wuerzler KK, Kotzsch A, Schliermann A, Schmitz W, Kuebler AC, Sebald W, Nickel J: GDF-5 can act as a context-dependent BMP-2 antagonist. In: BMC Biol. vol. 13, 2015/09/20 edn; 2015: 77.
Kleinhans C, Mohan RR, Vacun G, Schwarz T, Haller B, Sun Y, Kahlig A, Kluger P, Finne-Wistrand A, Walles H et al: A perfusion bioreactor system efficiently generates cell-loaded bone substitute materials for addressing critical size bone defects. In: Biotechnol J. 2015.
Lühmann T, Jones G, Gutmann M, Rybak JC, Nickel J, Rubini M, Meinel L: Bio-orthogonal immobilization of fibroblast growth factor 2 for spatial controlled cell proliferation. In: ACS Biomaterials Science & Engineering. vol. in press; 2015.
M J, F G, NW B, C U, H W, J H: Development and application of three-dimensional skin equivalents for the investigation of percutaneous worm invasion. In: Experimental Parasitology vol. 150, 2015 Jan 12 edn; 2015: 22-30.
Meir M, Flemming S, Burkard N, Bergauer L, Metzger M, Germer CT, Schlegel N: Glial cell line-derived neurotrophic factor (GDNF) promotes barrier maturation and wound healing in intestinal epithelial cells in vitro. In: Am J Physiol Gastrointest Liver Physiol. 2015: ajpgi 00357 02014.
Rossi A, Appelt-Menzel A, Kurdyn S, Walles H, Groeber F: Generation of a three-dimensional full thickness skin equivalent and automated wounding. In: J Vis Exp. 2015.
Schacht K. JT, Schweinlin M., Ewald A., Groll J., Scheibel T.: Biofabrication of cell-loaded 3D spider silk constructs. In: Angew Chem Int Ed Engl vol. 54; 2015: 2816-2820.
Schmid F, Schwarz T, Schuberthan W, Klos M, Walles H, Hansmann J, Groeber F: Applicability of a Dual-Arm Robotic System for Automated Downstream Analysis of Epidermal Model. In: Applied In Vitro Toxicology. 2015.
Suliman S, Xing Z, Wu X, Xue Y, Pedersen TO, Sun Y, Doskeland AP, Nickel J, Waag T, Lygre H et al: Release and bioactivity of bone morphogenetic protein-2 are affected by scaffold binding techniques in vitro and in vivo. In: J Control Release. vol. 197, 2014/12/03 edn; 2015: 148-157.
T. S-Y, Rossi A, K.H. H, F. P, J. G, MJ. B-P: Neuregulin encapsulation and biocompatibility studies in a model of myocardial ischemia. In: Tissue Engineering Part A. 2015.
2014
Alepee N, Bahinski T, Daneshian M, De Wever B, Fritsche E, Goldberg A, Hansmann J, Hartung T, Haycock J, Hogberg H et al: State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. In: ALTEX. vol. 31; 2014: 441-477.
Delling U BW, Metzger M, Ludewig E, Winter K, Jülke H.: In vivo tracking and fate of intraarticularly injected superparamagnetic iron oxide particle-labeled multipotent stromal cells in an ovine model of osteoarthritis. In: Cell Transplantation. vol. DEC 2014; 2014.
Groeber F, Engelhardt L, Egger S, Werthmann H, Monaghan M, Walles H, Hansmann J: Impedance Spectroscopy for the Non-Destructive Evaluation of In Vitro Epidermal Models. In: Pharm Res. 2014.
Heinlein A MM, Walles H, Buettner A.: Transport of hop aroma compounds across Caco-2 monolayers. In: Food Funct. 2014: 2719-2730.
Hetz S, Acikgoez A, Moll C, Jahnke H-G, Robitzki AA, Metzger R, Metzger M: Age-related gene expression analysis in enteric ganglia of human colon after laser microdissection. In: Frontiers in Aging Neuroscience. vol. 6; 2014.
Hetz S, Acikgoez A, Voss U, Nieber K, Holland H, Hegewald C, Till H, Metzger R, Metzger M: In vivo transplantation of neurosphere-like bodies derived from the human postnatal and adult enteric nervous system: a pilot study. In: PloS One vol. 9; 2014.
Hetz S, Acikgoez A, Voss U, Nieber K, Holland H, Hegewald C, Till H, Metzger R, Metzger M: In vivo transplantation of neurosphere-like bodies derived from the human postnatal and adult enteric nervous system: a pilot study. In: PLoS One. vol. 9; 2014: e93605.
Hetz S AA, Moll C, Jahnke HG, Robitzki AA, Metzger R, Metzger M: Age related analysis of enteric ganglia of human colon using laser microdissection. In: Front Neuroscience. vol. 15; 2014: 276.
Hetz S AA, Voss U, Nieber K, Holland H, Hegewald C, Till H, Metzger R, Metzger M: In vivo transplantation of neurosphere-like bodies derived from the human postnatal and adult enteric nervous system: a pilot study. In: PloS One. vol. 9; 2014: e93605.
Markenstein L, Appelt-Menzel A, Metzger M, Wenz G: Conjugates of methylated cyclodextrin derivatives and hydroxyethyl starch (HES): Synthesis, cytotoxicity and inclusion of anaesthetic actives. In: Beilstein J Org Chem. vol. Beilstein J. Org. Chem. 2014, 10, 3087–3096. doi:10.3762/bjoc.10.325; 2014.
Raeth S, Sacchetti B, Siegel G, Mau-Holzmann UA, Hansmann J, Vacun G, Hauk TG, Pfizenmaier K, Hausser A: A mouse bone marrow stromal cell line with skeletal stem cell characteristics to study osteogenesis in vitro and in vivo. In: Stem Cells Dev. vol. 23; 2014: 1097-1108.
Rossi A, Fecher D, Egner S, Schweinlin M, Steinke M: Humane 3D-in vitro-Testsysteme für die präklinische Forschung. In: Biospektrum. vol. 04.14; 2014.
Steinke M, Dally I, Friedel G, Walles H, Walles T: Host-integration of a tissue-engineered airway patch: 2-year follow-up in a single patient. In: Tissue Eng Part A. vol. 21; 2014.
Steinke M, Gross R, Walles H, Gangnus R, Schutze K, Walles T: An engineered 3D human airway mucosa model based on an SIS scaffold. In: Biomaterials. vol. 35; 2014: 7355-7362.
Stratmann AT FD, Wangorsch G, Göttlich C, Walles T, Walles H, Dandekar T, Dandekar G, Nietzer SL: Establishment of a human 3D lung cancer model based on a biological tissue matrix combined with a Boolean in silico model. In: Molecular Oncology. vol. 8; 2014: 351-365.
Zeplin PH, Berninger AK, Maksimovikj NC, van Gelder P, Scheibel T, Walles H: Verbesserung der Biokompatibilität von Silikonimplantaten durch Spinnenseidenbeschichtung: Immunhistochemische Untersuchungen zum Einfluss auf die Kapselbildung. In: Handchir Mikrochir plast Chir. vol. 46, 08.12.2014 edn; 2014: 336-341.
Zeplin PH, Maksimovikj NC, Jordan MC, Nickel J, Lang G, Leimer AH, Roemer L, Scheibel T: Spider Silk Coatings as a Bioshield to Reduce Periprosthetic Fibrous Capsule Formation. In: Advanced Functional Materials. vol. 24; 2014: 2658-2666.
Fraunhofer Translationszentrum für Regenerative Therapien TLZ-RT