Publications

JahrTitel/AutorDokumentart
2021Improvement of the Electronic-Neuronal Interface by Natural Deposition of ECM
Weigel, Tobias; Brennecke, Julian; Hansmann, Jan
Zeitschriftenaufsatz
2021In vitro skin culture media influence the viability and inflammatory response of primary macrophages
Griffoni, Chiara; Neidhart, Berna; Yang, Ke; Groeber-Becker, Florian; Maniura-Weber, Katharina; Dandekar, Thomas; Walles, Heike; Rottmar, Markus
Zeitschriftenaufsatz
2021Poly(2-ethyl-2-oxazoline-co-N -propylethylene imine)s by controlled partial reduction of poly(2-ethyl-2-oxazoline): Synthesis, characterization and cytotoxicity
Halupczok, Sebastian; Pfister, Maria; Ringhand, Annemarie; Fetsch, Corinna; Cubukova, Alevtina; Appelt-Menzel, Antje; Luxenhofer, Robert
Zeitschriftenaufsatz
2021Triple co-culture and perfusion bioreactor for studying the interaction between Neisseria gonorrhoeae and neutrophils: A novel 3D tissue model for bacterial infection and immunity
Heydarian, Motaharehsadat; Schweinlin, Matthias; Schwarz, Thomas; Rawal, Ravisha; Walles, Heike; Metzger, Marco; Rudel, Thomas; Kozjak-Pavlovic, Vera
Zeitschriftenaufsatz
Diese Publikationsliste wurde aus der Publikationsdatenbank Fraunhofer-Publica erstellt.

JahrTitel/AutorDokumentart
20203D printing of bioreactors in tissue engineering: A generalised approach
Gensler, Marius; Leikeim, Anna; Möllmann, Marc; Komma, Miriam; Heid, Susanne; Müller, Claudia; Boccaccini, Aldo R.; Salehi, Sahar; Groeber-Becker, Florian; Hansmann, Jan
Zeitschriftenaufsatz
2020An Advanced Human Intestinal Coculture Model Reveals Compartmentalized Host and Pathogen Strategies during Salmonella Infection
Schulte, Leon N.; Schweinlin, Matthias; Westermann, Alexander J.; Janga, Harshavardhan; Santos, Sara C.; Appenzeller, Silke; Walles, Heike; Vogel, Jörg; Metzger, Marco
Zeitschriftenaufsatz
2020Analysis of tissue microstructure with Mueller microscopy: Logarithmic decomposition and Monte Carlo modeling
Li, Pengcheng; Lee, Hee Ryung; Chandel, Shubham; Lotz, Christian; Groeber-Becker, Florian Kai; Dembski, Sofia; Ossikovski, Razvigor; Ma, Hui; Novikova, Tatiana
Zeitschriftenaufsatz
2020Bacterial nanocellulose as novel carrier for intestinal epithelial cells in drug delivery studies
Fey, Christina; Betz, Jana; Rosenbaum, Corinna; Kralisch, Dana; Vielreicher, Martin; Friedrich, Oliver; Metzger, Marco; Zdzieblo, Daniela
Zeitschriftenaufsatz
2020Biomimetic in vitro test system for evaluation of dental implant materials
Ehlicke, Franziska; Berndt, Jonathan; Marichikj, Nina; Steinmüller-Nethl, Doris; Walles, Heike; Berndt, Ernst-Ulrich; Hansmann, Jan
Zeitschriftenaufsatz
2020Combining Ultra-High Drug-Loaded Micelles and Injectable Hydrogel Drug Depots for Prolonged Drug Release
Lübtow, Michael M.; Lorson, Thomas; Finger, Tamara; Groeber-Becker, Florian Kai; Luxenhofer, Robert
Zeitschriftenaufsatz
2020Connecting cancer pathways to tumor engines: A stratification tool for colorectal cancer combining human in vitro tissue models with boolean in silico models: Article number 28
Baur, Florentin; Nietzer, Sarah L.; Kunz, Meik; Saal, Fabian; Jeromin, Julian; Matschos, Stephanie; Linnebacher, Michael; Walles, Heike; Dandekar, Thomas; Dandekar, Gudrun
Zeitschriftenaufsatz
2020Delivery of antiseptic solutions by a bacterial cellulose wound dressing: Uptake, release and antibacterial efficacy of octenidine and povidone-iodine
Bernardelli de Mattos, Ives; Nischwitz, Sebastian P.; Tuca, Alexandru-Cristian; Groeber-Becker, Florian; Funk, Martin; Birngruber, Thomas; Mautner, Selma I.; Kamolz, Lars-Peter; Holzer, Judith C.J.
Zeitschriftenaufsatz
2020Development of a bioreactor system for pre-endothelialized cardiac patch generation with enhanced viscoelastic properties by combined collagen I compression and stromal cell culture
Krziminski, Carolin; Kammann, Sebastian; Hansmann, Jan; Edenhofer, Frank; Dandekar, Gudrun; Walles, Heike; Leistner, Marcus
Zeitschriftenaufsatz
2020DNA Stability, Regeneration Capacity, and Mucociliary Differentiation of Human Nasal Mucosa Cells in Tissue Systems
Ickrath, Pascal; Ickrath, Katrin; Steinke, Maria; Scherzad, Agma; Kleinsasser, Norbert; Lodes, Nina; Bregenzer, Maximilian; Hagen, Rudolf; Hackenberg, Stephan
Zeitschriftenaufsatz
2020Enteroids Generated from Patients with Severe Inflammation in Crohn's Disease Maintain Alterations of Junctional Proteins
Meir, M.; Salm, J.; Fey, C.; Schweinlin, M.; Kollmann, C.; Kannapin, F.; Germer, C.-T.; Waschke, J.; Beck, C.; Burkard, N.; Metzger, M.; Schlegel, N.
Zeitschriftenaufsatz
2020Epidermal Regeneration Induced by Comfrey Extract: A Study by Light and Electron Microscopy
Dähnhardt , D.; Dähnhardt-Pfeiffer, S.; Groeber-Becker, F.; Fölster-Holst, R.; Schmidt, M.
Zeitschriftenaufsatz
2020Glucose transporters in pancreatic islets
Berger, Constantin; Zdzieblo, Daniela
Zeitschriftenaufsatz
2020Human iPSC-Derived Blood-Brain Barrier Models: Valuable Tools for Preclinical Drug Discovery and Development?
Appelt-Menzel, Antje; Oerter, Sabrina; Mathew, Sanjana; Haferkamp, Undine; Hartmann, Carla; Jung, Matthias; Neuhaus, Winfried; Pless, Ole
Zeitschriftenaufsatz
2020In silico signaling modeling to understand cancer pathways and treatment responses
Kunz, Meik; Jeromin, Julian; Fuchs, Maximilian; Christoph, Jan; Veronesi, Giulia; Flentje, Michael; Nietzer, Sarah; Dandekar, Gudrun; Dandekar, Thomas
Zeitschriftenaufsatz
2020An In Vitro Barrier Model of the Human Submandibular Salivary Gland Epithelium Based on a Single Cell Clone of Cell Line HTB-41: Establishment and Application for Biomarker Transport Studies
Lin, Grace C.; Smajlhodzic, Merima; Bandian, Anna-Maria; Friedl, Heinz-Peter; Leitgeb, Tamara; Oerter, Sabrina; Stadler, Kerstin; Giese, Ulrich; Peham, Johannes R.; Bingle, Lynne; Neuhaus, Winfried
Zeitschriftenaufsatz
2020In Vitro Blood-Brain Barrier Permeability and Cytotoxicity of an Atorvastatin-Loaded Nanoformulation Against Glioblastoma in 2D and 3D Models
Lübtow, Michael M.; Oerter, Sabrina; Quader, Sabina; Jeanclos, Elisabeth; Cubukova, Alevtina; Krafft, Marion; Haider, Malik Salman; Schulte, Clemens; Meier, Laura; Rist, Maximilian; Sampetrean, Oltea; Kinoh, Hiroaki; Gohla, Antje; Kataoka, Kazunori; Appelt-Menzel, Antje; Luxenhofer, Robert
Zeitschriftenaufsatz
2020Inflammation-induced tissue damage mimicking GvHD in human skin models as test-platform for immunotherapeutics
Wallstabe, Julia; Bussemer, Lydia; Groeber-Becker, Florian; Freund, Lukas; Alb, Miriam; Dragan, Mariola; Waaga-Gasser, Ana Maria; Jakubietz, Rafael; Kneitz, Hermann; Rosenwald, Andreas; Rebhan, Silke; Walles, Heike; Mielke, Stephan
Zeitschriftenaufsatz
2020Inhibition of TGF-β-receptor signaling augments the antitumor function of ROR1-specific CAR T-cells against triple-negative breast cancer
Stüber, Tanja; Monjezi, Razieh; Wallstabe, Lars; Kühnemundt, Johanna; Nietzer, Sarah Louise; Dandekar, Gudrun; Wöckel, Achim; Einsele, Hermann; Wischhusen, Jörg; Hudecek, Michael
Zeitschriftenaufsatz
2020Investigation of Cellular Function and DNA Integrity during 2D in vitro Culture of Human Salivary Gland Epithelial Cells
Burghartz, Marc; Taeger, Johannes; Metzger, Marco; Scherzad, Agmal; Gehrke, Thomas; Ickrath, Pascal; Kolb, Evelyn; Kleinsasser, Norbert; Hagen, Rudolf; Hackenberg, Stephan
Zeitschriftenaufsatz
2020Investigation on Ciliary Functionality of Different Airway Epithelial Cell Lines in Three-Dimensional Cell Culture
Lodes, Nina; Seidensticker, Katharina; Perniss, Alexander; Nietzer, Sarah; Oberwinkler, Heike; May, Tobias; Walles, Thorsten; Hebestreit, Helge; Hackenberg, S.; Steinke, Maria
Zeitschriftenaufsatz
2020Matrix decoded - A pancreatic extracellular matrix with organ specific cues guiding human iPSC differentiation
Berger, Constantin; Bjørlykke, Yngvild; Hahn, Lukas; Mühlemann, Markus; Kress, Sebatian; Walles, Heike; Luxenhofer, Robert; Ræder, Helge; Metzger, Marco; Zdzieblo, Daniela
Zeitschriftenaufsatz
2020Nanotopographical Coatings Induce an Early Phenotype-Specific Response of Primary Material-Resident M1 and M2 Macrophages
Schmitz, Tobias; Jannasch, Maren; Weigel, Tobias; Moseke, Claus; Gbureck, Uwe; Groll, Jürgen; Walles, Heike; Hansmann, Jan
Zeitschriftenaufsatz
2020NO-GC in Pericytes as Modulator of Skin Fibrosis: European Tissue Repair Society Annual Meeting — 2019 Isarforum Munich, Germany
Reigl, A.; Groeber-Becker, F.; Friebe, A.; Groneberg, D.
Abstract
2020Recombinant Adenosine Deaminase Ameliorates Inflammation, Vascular Disease, and Fibrosis in Preclinical Models of Systemic Sclerosis
Zhang, Yun; Zhu, Honglin; Layritz, Florian; Luo, Hui; Wohlfahrt, Thomas; Chen, Chih-Wei; Soare, Alina; Bergmann, Christina; Ramming, Andreas; Groeber, Florian; Reuter, Christian; Fornasini, GianFranco; Soukhareva, Nadejda; Schreiber, Brian; Ramamurthy, Santosh; Amann, Kerstin; Schett, Georg; Distler, Jörg H.W
Zeitschriftenaufsatz
2020Regulatory-Compliant Validation of a Highly Sensitive qPCR for Biodistribution Assessment of Hemophilia A Patient Cells
Bittorf, P.; Bergmann, T.; Merlin, S.; Olgasi, C.; Pullig, O.; Sanzenbacher, R.; Zierau, M.; Walles, H.; Follenzi, A.; Braspenning, J.
Zeitschriftenaufsatz
2020Sterubin: Enantioresolution and configurational stability, enantiomeric purity in nature, and neuroprotective activity in vitro and in vivo
Hofmann, Julian; Fayez, Shaimaa; Scheiner, Matthias; Hoffmann, Matthias; Oerter, Sabrina; Appelt-Menzel, Antje; Maher, Pamela; Maurice, Tangui; Bringmann, Gerhard; Decker, Michael
Zeitschriftenaufsatz
2020A three-dimensional intestinal tissue model reveals factors and small regulatory RNAs important for colonization with Campylobacter jejuni
Alzheimer, Mona; Svensson, Sarah L.; König, Fabian; Schweinlin, Matthias; Metzger, Marco; Walles, Heike; Sharma, Cynthia Mira
Zeitschriftenaufsatz
2020Vascularized Three-Dimensional Models of Human Skin Fibrosis
Matei, A.E.; Chen, C.W.; Kiesewetter, L.; Györfi, A.H.; Li, Y.N; Trinh-Minh, T.; Kuppevelt, T. van; Hansmann, J.; Juengel, A.; Schett, G; Groeber-Becker, F.; Distler, J.
Zeitschriftenaufsatz
Diese Publikationsliste wurde aus der Publikationsdatenbank Fraunhofer-Publica erstellt.

JahrTitel/AutorDokumentart
2019358 Human-based T cell-skin models for graft-versus-host disease: Innate Immunity and Inflammation
Geiger, F.; Tumbev, Y.; Groeber-Becker, F.K.; Berberich-Siebelt, F.
Abstract
2019A 3D-hemi-cornea wound healing model for pre-clinical testing
Kampik, D.; Tarau, I.S.; Han, H.; Walles, H.; Groeber-Becker, F.K.; Hillenkamp, J.; Lotz, C.
Abstract
2019509 Melanoma skin equivalents for studying metastasis and anti-melanoma therapies: Melanoma and Other Skin Cancers
Leikeim, A.; Junger, C.; Kliche, J.; Komma, M.; Schmidt, F.; Groeber-Becker, F.
Abstract
2019Automated real-time monitoring of human pluripotent stem cell aggregation in stirred tank reactors
Schwedhelm, Ivo; Zdzieblo, Daniela; Appelt-Menzel, Antje; Berger, Constantin; Schmitz, Tobias; Schuldt, Bernhard; Franke, Andre; Müller, Franz-Josef; Pless, Ole; Schwarz, Thomas; Wiedemann, Philipp; Walles, Heike; Hansmann, Jan
Zeitschriftenaufsatz
2019A coculture system composed of THP-1 cells and 3D reconstructed human epidermis to assess activation of dendritic cells by sensitizing chemicals after topical exposure
Schellenberger, Mario T.; Bock, Udo; Hennen, Jennifer; Groeber-Becker, Florian Kai; Walles, Heike; Blömeke, Brunhilde
Zeitschriftenaufsatz
2019Continuous pH monitoring in wounds using a composite indicator dressing - A feasibility study
Nischwitz, S.P.; Bernardelli de Mattos, I.; Hofmann, E.; Groeber-Becker, F.; Funk, M.; Mohr, G.J.; Branski, L.K.; Mautner, S.I.; Kamolz, L.P.
Zeitschriftenaufsatz
2019Cultivation of hMSCs in Human Plasma Prevents the Cytotoxic and Genotoxic Potential of ZnO-NP In Vitro
Scherzad, Agmal; Meyer, Till, J.; Ickrath, Pascal; Gehrke, Thomas; Bregenzer, Maximillian; Hagen, Rudolf; Dembski, Sofia; Hackenberg, Stephan
Zeitschriftenaufsatz
2019Digital histology with Mueller microscopy: How to mitigate an impact of tissue cut thickness fluctuations
Lee, Hee Ryung; Li, Pengcheng; Yoo, Thomas Sang Hyuk; Lotz, Christian; Groeber-Becker, Florian Kai; Dembski, Sofia; Garcia-Caurel, Enric; Ossikovski, Razvigor; Ma, Hui; Novikova, Tatiana
Zeitschriftenaufsatz
2019Drug induced micellization into ultra-high capacity and stable curcumin nanoformulations: Physico-chemical characterization and evaluation in 2D and 3D in vitro models
Lübtow, Michael M.; Nelke, Lena C.; Seifert, Julia; Kühnemundt, Johanna; Sahay, Gaurav; Dandekar, Gudrun; Nietzer, Sarah L.; Luxenhofer, Robert
Zeitschriftenaufsatz
2019A fast and simple fluorometric method to detect cell death in 3D intestinal organoids
Bode, Konstantin J.; Mueller, Stefanie; Schweinlin, Matthias; Metzger, Marco; Brunner, Thomas
Zeitschriftenaufsatz
2019Functionalisation of TiO2 nanoparticles with a fluorescent organosilane: A synergy enabling their visualisation in biological cells and an enhanced photocatalytic activity
Wintzheimer, Stefan; Génin, Emilie; Vellutini, Luc; Bourdon, Gwénaëlle le; Kessler, Michael; Hackenberg, Stephan; Dembski, Sofia; Heuzé, Karine
Zeitschriftenaufsatz
2019Generation of porous 3D-scaffolds based on electrospun nanofibers
Weigel, Tobias; Schmitz, Tobias; Jannasch, Maren; Schürlein, Sebastian; Al-Hijailan, Reem; Suliman, Salwa; Walles, Heike; Hansmann, Jan
Abstract
2019Hot Topic: A Human In Vitro Model for Epidermal Burn Wounds
Schneider, Verena; Bernardelli de Mattos, Yves; Funk, Martin; Groeber-Becker, Florian Kai
Abstract
2019Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair
Colunga, Thomas; Hayworth, Miranda; Kress, Sebastian; Reynolds, David M.; Chen, Luoman; Nazor, Kristopher L.; Baur, Johannes; Singh, Amar M.; Loring, Jeanne F.; Metzger, Marco; Dalton, Stephen
Zeitschriftenaufsatz
2019Impedance spectroscopy as a method to discriminate between all GHS categories for eye irritation in vitro
Lotz, C.; Kieswetter, L.; Hansmann, J.; Walles, H.; Groeber-Becker, F.
Abstract
2019Improved metal allergen reactivity of artificial skin models by integration of Toll-like receptor 4-positive cells
Frings, Verena G.; Müller, Damaris; Storz, Gabriel; Rossi, Angela; Sennefelder, Helga; Adam, Christian; Goebeler, Matthias; Groeber-Becker, Florian K.; Schmidt, Marc
Zeitschriftenaufsatz
2019An in vitro model mimics the contact of biomaterials to blood components and the reaction of surrounding soft tissue
Jannasch, Maren; Gaetzner, Sabine; Groeber, Florian; Weigel, Tobias; Walles, Heike; Schmitz, Tobias; Hansmann, Jan
Zeitschriftenaufsatz
2019Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells as a Cellular Model to Study Neisseria meningitidis Infection: Article number 1181
Martins Gomes, Sara F.; Westermann, Alexander J.; Sauerwein, Till; Hertlein, Tobias; Förstner, Konrad U.; Ohlsen, Knut; Metzger, Marco; Shusta, Eric V.; Kim, Brandon J.; Appelt-Menzel, Antje; Schubert-Unkmeir, Alexandra
Zeitschriftenaufsatz
2019Inflammatory reactivity of reconstructed human epidermis to metal haptens by integration of TLR4-positive cells
Frings, Verena Gerlinde; Müller, Daniel; Storz, G.; Sennefelder, H.; Adam, C.; Goebeler, Matthias; Groeber-Becker, Florian Kai; Schmidt, M.
Abstract
2019Measles Virus Infection Fosters Dendritic Cell Motility in a 3D Environment to Enhance Transmission to Target Cells in the Respiratory Epithelium
Derakhshani, Shaghayegh; Kurz, Andreas; Japtok, Lukasz; Schumacher, Fabian; Pilgram, Lisa; Steinke, Maria; Kleuser, Burkhard; Sauer, Markus; Schneider-Schaulies, Sibylle; Avota, Elita
Zeitschriftenaufsatz
2019Mueller microscopy of full thickness skin models combined with image segmentation
Lee, Hee Ryung; Lotz, Christian; Groeber-Becker, Florian Kai; Dembski, Sofia; Garcia-Caurel, Enric; Ossikovski, Razvigor; Novikova, Tatiana
Konferenzbeitrag
2019Neurotrophic factor GDNF regulates intestinal barrier function in inflammatory bowel disease
Meir, M.; Burkard, N.; Ungewiß, H.; Diefenbacher, M.; Flemming, S.; Kannapin, F.; Germer, C.-T.; Schweinlin, M.; Metzger, M.; Waschke, J.; Schlegel, N.
Zeitschriftenaufsatz
2019Patient-derived in vitro skin models for investigation of small fiber pathology
Karl, Franziska; Wußmann, Maximiliane; Kreß, Luisa; Malzacher, Tobias; Fey, Phillip; Groeber-Becker, Florian; Üçeyler, Nurcan
Zeitschriftenaufsatz
2019Postnatal human enteric neurospheres show a remarkable molecular complexity
Schmitteckert, S.; Mederer, T.; Röth, R.; Günther, P.; Holland-Cunz, S.; Metzger, M.; Samstag, Y.; Schröder-Braunstein, J.; Wabnitz, G.; Kurzhals, S.; Scheuerer, J.; Beretta, C.A.; Lasitschka, F.; Rappold, G.A.; Romero, P.; Niesler, B.
Zeitschriftenaufsatz
2019The Radiosensitizing Effect of Zinc Oxide Nanoparticles in Sub-Cytotoxic Dosing is Associated with Oxidative Stress In Vitro
Meyer, Till Jasper; Scherzad, Agmal; Moratin, Helena; Gehrke, Thomas; Killisperger, Julian; Hagen, Rudolf; Wohlleben, Gisela; Polat, Bülent; Dembski, Sofia; Kleinsasser, Norbert Helmut; Hackenberg, Stephan
Zeitschriftenaufsatz
2019Reepithelialization in focus: Non-invasive monitoring of epidermal wound healing in vitro
Kiesewetter, Lisa; Littau, Laura; Walles, Heike; Boccaccini, Aldo R.; Groeber-Becker, Florian
Zeitschriftenaufsatz
2019Reepithelialization in Focus: Rapid Screening of Wound Closure Using Organotypic Skin Models
Kiesewetter, Lisa; Littau, Laura; Boccaccini, Aldo R.; Walles, Heike; Groeber-Becker, Florian Kai
Abstract
2019ROR1-CAR T cells are effective against lung and breast cancer in advanced microphysiologic 3D tumor models
Wallstabe, Lars; Göttlich, Claudia; Nelke, Lena C.; Kühnemundt, Johanna; Schwarz, Thomas; Nerreter, Thomas; Einsele, Hermann; Walles, Heike; Dandekar, Gudrun; Nietzer, Sarah L.; Hudecek, Michael
Zeitschriftenaufsatz
2019Synthesis and characterization of NIR dye-doped nanoparticles for in vivo medical imaging
Schneider, C.; Dembski, S.; Miller, F.; Riess, T.; Jose, J.
Abstract
2019Transdifferentiating reconstructed human epidermis (RHE) to corneal epithelium through retinoic acid
Lotz, C.; Seliger, R.; Littau, L.; Akyuerek, D.; Groeber-Becker, F.K.
Abstract
2019Uptake of PHMB in a bacterial nanocellulose-based wound dressing: A feasible clinical procedure
Mattos, Ives Bernardelli de; Holzer, Judith C.J.; Tuca, Alexandru-Cristian; Groeber-Becker, Florian Kai; Funk, Martin; Popp, Daniel; Mautner, Selma; Birngruber, Thomas; Kamolz, Lars-Peter
Zeitschriftenaufsatz
2019Vascularised human skin equivalents as a novel in vitro model of skin fibrosis and platform for testing of antifibrotic drugs
Matei, Alexandru-Emil; Chen, Chih-Wei; Kiesewetter, Lisa; Györfi, Andrea-Hermina; Li, Yi-Nan; Trinh-Minh, Thuong; Xu, Xiaohan; Tran Manh, Cuong; Kuppevelt, Toin van; Hansmann, Jan; Jüngel, Astrid; Schett, Georg; Groeber-Becker, Florian; Distler, Jörg H.W.
Zeitschriftenaufsatz
Diese Publikationsliste wurde aus der Publikationsdatenbank Fraunhofer-Publica erstellt.

2018

  • Lotz C., Kiesewetter L., Schmid F.F., Hansmann, J., Walles H. & Groeber-Becker F.:
    Replacing the Draize eye test: Impedance spectroscopy as a 3R method to discriminate between all GHS categories for eye irritation.

Das Augenlicht ist einer unserer wertvollsten Sinne. Um unsere Augen vor schädlichen Substanzen zu schützen, müssen chemische Stoffe in Bezug auf ihr Schädigungspotenzial getestet werden. Eine Standardmethode dafür ist der Draize-Test, bei dem Kaninchen in Tierversuchen eingesetzt werden. Das Translationszentrum Regenerative Therapien hat eine Alternative entwickelt, die ohne Tierversuche auskommt. Die neue Methode basiert auf einem In-vitro-Testmodell der menschlichen Cornea/Augenhornhaut und einem zerstörungsfreien Messsystem. Diese Kombination ermöglicht die Bewertung und Einordnung von Substanzen in die drei Kategorien des international standardisierten Klassifikationssystems der Augenreizungen mit hoher Genauigkeit und Zuverlässigkeit mit einem In-vitro-Test. Damit könnte der Draize-Test ersetzt werden, gemäß dem 3R Prinzip zur Verringerung von Tierversuchen.

>> Hier gelangen Sie zum vollständigen Artikel über »Replacing the Draize eye test: Impedance spectroscopy as a 3R method to discriminate between all GHS categories for eye irritation« 

  • Berger C., Bjorlykke Y., Muhlemann M., Raeder H., Walles H., Metzger M., Zdzieblo D.:
    A pancreas-specific ECM scaffold – human iPS cell culture and pancreatic differentiation goes 3D. Diabetologia 2018, 61: S.192-S.192.
  • Burghartz M., Lennartz S., Schweinlin M., Hagen R., Kleinsasser N., Hackenberg S., Steussloff G., Scherzad A., Radeloff K., Ginzkey C. et al.:
    Development of Human Salivary Gland-Like Tissue In Vitro. Tissue Eng Part A 2018, 24 (3-4): 301-309.
  • Chen MJ., Whiteley JP., Please CP., Schwab A., Ehlicke F., Waters SL., Byrne HM.:
    Inducing chondrogenesis in MSC/chondrocyte co-cultures using exogenous TGF-beta: a mathematical model. J Theor Biol 2018, 439: 1-13.
  • Confalonieri D., Schwab A., Walles H., Ehlicke F.: Advanced Therapy Medicinal Products:
    A Guide for Bone Marrow-derived MSC Application in Bone and Cartilage Tissue Engineering. Tissue Eng Part B-Rev 2018, 24(2): 155-169.
  • Ditgen D., Anandarajah EM., Reinhardt A., Younis AE., Witt S., Hansmann J., Lorenz E., Garcia-Hernandez M., Paclik D., Soblik H. et al:
    Comparative characterization of two galectins excreted-secreted from intestine-dwelling parasitic versus free-living females of the soil-transmitted nematode Strongyloides
    . Mol Biochem Parasitol 2018, 225: 73-83.
  • Gottlich C., Kunz M., Zapp C., Nietzer SL., Walles H., Dandekar T., Dandekar G.:
    A combined tissue-engineered/insilico signature tool patient stratification in lung cancer. Mol Oncol 2018, 12(8): 1264-1285.
  • Hafen B., Wiesner S., Schlegelmilch K., Keller A., Seefried L., Ebert R., Walles H., Jakob F., Schutze N.:
    Physical contact between mesenchymal stem cells and endothelial precursors induces distinct signatures with relevance to the very early phase of regeneration. J Cell Biochem 2018, 119(11): 9122-9140.
  • Kress S., Baur J., Otto C., Burkard N., Braspenning J., Walles H., Nickel J., Metzger M.:
    Evaluation of a Miniaturized Biologically Vascularized Scaffold in vitro and in vivo. Sci Rep 2018, 8:13.
  • Lohr D., Terekhov M., Weng AM., Schroeder A., Walles H., Schreiber LM.:
    Possible benefits of ultra high field MRI in cardiac diffusion tensor imaging. Eur J Heart Fail 2018, 20: 149-150
  • Lotz C., Kiesewetter L., Schmid FF., Hansmann J., Walles H., Groeber-Becker F.:
    Replacing the Draize eye test: Impedance spectroscopy as a 3R method to discriminate between all GHS categories for eye irritation. Sci Rep 2018, 8:13.
  • Massie I., Spaniol K., Barbian A., Geerling G., Metzger M., Schrader S.:
    Development of lacrimal gland spheroids for lacrimal gland tissue regeneration. J Tissue Eng Regen Med 2018, 12(4): E2001-E2009.
  • Muhlemann M., Zdzieblo D., Friedrich A., Berger C., Otto C., Walles H., Koepsell H., Metzger M.:
    Altered pancreatic islet morphology and function in SGLT1 knockout mice on a glucose-deficient, fat-enriched diet. Mol Metab 2018, 13: 67-76.
  • Mumcuoglu D., de Miguel L., Jekhmane S., Siverino C., Nickel J., Mueller TD., van Leeuwen JP., van Osch GJ., Kluijtmans SG.:
    Collagen I derived recombinant protein microspheres as novel delivery vehicles for bone morphogenetic protein-2. Mater Sci Eng C-Mater Biol Appl 2018, 84: 271-280.
  • Munoz MS., Confalonieri D., Walles H., van Dongen E., Dandekar G.:
    Recombinant Collagen I Peptide Microcarriers for Cell Expansion and Their Potential Use As Cell Delivery System in a Bioreactor Model. J Vis Exp 2018(132): 11.
  • Nickel J., ten Dijke P., Mueller TD.:
    TGF-beta family co-receptor function and signaling. Acta Biochim Biophys Sin 2018, 50(1): 12-36.
  • Olgasi C., Merlin S., Bittorf P., Mazzuca D., Stolzing A., Toleikidis P., Zierau M., Follenzi A., Braspenning J., Bergmann T.:
    HemAcure: Application of combined gene and cell therapy within an implantable therapeutic device for the treatment of severe haemophilia A. Haemophilia 2018, 24: 66-66.
  • Olgasi C., Merlin S., Borsotti C., Bergmann T., Mazzucca DM., Stolzing A., Zierau M., Toleikis PM., Braspenning J., Follenzi A.:
    Application of combined gene and cell therapy within an implantable therapeutic device for the treatment of severe haemophilia A. Hum Gene Ther 2018, 29(12): A61-A61.
  • Pali M., Terekhov M., Wittke C., Wagner N., Schroeder A., Walles H., Erguen S., Zernecke-Madsen A., Schreiber LM.:
    High-Resolution and Semidynamic Vessel Wall Imaging Kinetics obtained from Stable Radical MRI in ex-vivo Porcine Aorta. Eur J Heart Fail 2018, 20: 522-523.
  • Pers YM., Quentin J., Feirreira R., Espinoza F., Abdellaoui N., Erkilic N., Dufourcq-Lopez E., Pullig O., Noth U., Jorgensen C. et al.:
    Injection of Adipose-Derived Stromal Cells in the Knee of Patients with Severe Osteoarthritis has a Systemic Effect and Promotes an Anti-Inflammatory Phenotype of Circulating Immune Cells. Theranostics 2018, 8(20): 5519-5528.
  • Ramani-Mohan RK., Schwedhelm I., Finne-Wistrand A., Krug M., Schwarz T., Jakob F., Walles H., Hansmann J.:
    Deformation strain is the main physical driver for skeletal precursors to undergo osteogenesis in earlier stages of osteogenic cell maturation. J Tissue Eng Regen Med 2018, 12(3): E1474-E1479.
  • Ribitsch I., Peham C., Ade N., Durr J., Handschuh S., Schramel JP., Vogl C., Walles H., Egerbacher M., Jenner F.:
    Structure-Function relationships of equine menisci. PLoS One 2018, 13(3): 17.
  • Schellenberger MT., Bock U., Hennen J., Grober-Becker F., Walles H., Blomeke B.:
    An in vitro coculture system composed of THP-1 cells and 3D reconstructed human epidermis to assess activation of dendritic cells by sensitizing chemicals. Naunyn-Schmiedebergs Arch Pharmacol 2018, 391: S.49-S.49.
  • Schellenberger MT., Bock U., Hennen J., Groeber-Becker F., Wailes H., Blomeke B.:
    The use of a THP-1/3D reconstructed human epidermis (RHE) coculture system to assess the sensitizing potential of chemicals. Toxicol Lett 2018, 295: S.161-S.162.
  • Schliermann A., Nickel J.:
    Unraveling the Connection between Fibroblast Growth Factor and Bone Morphogenetic Protein Signaling. Int J Mol Sci 2018, 19(10): 17.
  • Schmid FF., Groeber-Becker F., Schwab S., Thude S., Goebeler M., Walles H., Hansmann J.:
    A Standardized Method Based on Pigmented Epidermal Models Evaluates Sensitivity Against UV-Irradiation. ALTEX-Altern Anim Exp 2018, 35(3): 390-396.
  • Schmid R, Tarau IS, Rossi A, Leonhardt S, Schwarz T., Schuerlein S., Lotz C., Hansmann J.:
    In Vivo-Like Culture Conditions in a Bioreactor Facilitate Improved Tissue Quality in Corneal Storage. Biotechnol J 2018, 13(1): 7.
  • Siverino C., Tabisz B., Luhmann T., Meinel L., Muller T., Walles H., Nickel J.:
    Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry. J Vis Exp 2018(133): 8.
  • Steinke M., Zunhammer F., Chatzopoulou EI., Teller H., Schutze K., Walles H., Radler JO., Gruttner C.:
    Rapid Analysis of Cell-Nanoparticle Interactions using Single-Cell Raman Trapping Microscopy. Angew Chem-Int Edit 2018, 57(18): 4946-4950.
  • Stuckensen K., Schwab A., Knauer M., Muinos-Lopez E., Ehlicke F., Reboredo J., Granero-Molto F., Gbureck U., Prosper F., Walles H. et al.:
    Tissue Mimicry in Morphology and Composition Promotes Hierarchical Matrix Remodeling of Invading Stem Cells in Osteochondral and Meniscus Scaffolds. Adv Mater 2018, 30(28): 7.
  • Weigel T., Schmitz T., Pfister T., Gaetzner S., Jannasch M., Al-Hijailan R., Schurlein S., Suliman S., Mustafa K., Hansmann J.:
    A three-dimensional hybrid pacemaker electrode seamlessly integrates into engineered, functional human cardiac tissue in vitro. Sci Rep 2018, 8:13.
  • Wintzheimer S., Szczerba W., Buzanich AG., Kashiwaya S., Klein A., Jaegermann W., Toupance T., Shmeliov A., Nicolosi V., Heuze K. et al.:
    Discovering the Determining Parameters for the Photocatalytic Activity of TiO2 Colloids Based on an Anomalous Dependence on the Specific Surface Area. Part Part Syst Charact 2018, 35(9): 10.

2017

  • Belka J, Weigel T, Berninger AK, Kurth DG, Nickel J:
    Growth and Differentiation of Myoblastic Precursor Cells on Thin Films of Metallo-Supramolecular Coordination Polyelectrolyte (MEPE). In: Advanced Materials Interfaces. vol. 4; 2017.
  • Confalonieri D, La Marca M, van Dongen EMWM, Walles H, Ehlicke F:
    An Injectable Recombinant Collagen I Peptide-Based Macroporous Microcarrier Allows Superior Expansion of C2C12 and Human Bone Marrow-Derived Mesenchymal Stromal Cells and Supports Deposition of Mineralized Matrix. In: Tissue Eng Part A. 2017: 12.
  • Christ B FC, Cubukova A, Walles H, Dembski S, Metzger M:
    Screening applications to test cellular fitness in Transwell(r) models after nanoparticle treatment
    . In: Methods in Molecular Biology. vol. 1601; 2017: 111-122.
  • Kimpton LS, Schwab A, Ehlicke F, Waters SL, Please CP, Whiteley JP, Byrne HM:
    A mathematical model for cell infiltration and proliferation in a chondral defect. In: Math Biosci. vol. 292; 2017: 46-56.
  • Lagler C, El-Mesery M, Kubler AC, Muller-Richter UDA, Stuhmer T, Nickel J, Muller TD, Wajant H, Seher A:
    The anti-myeloma activity of bone morphogenetic protein 2 predominantly relies on the induction of growth arrest and is apoptosis-independent. In: PLoS One. vol. 12, 2017/10/14 edn; 2017: e0185720
  • Nickel J, Ten Dijke P, Mueller TD:
    TGF-beta family co-receptor function and signaling. In: Acta Biochim Biophys Sin (Shanghai). 2018/01/03 edn; 2017.
  • Pawelec KM, Confalonieri D, Ehlicke F, van Boxtel HA, Walles H, Kluijtmans SGJM:
    Osteogenesis and mineralization of mesenchymal stem cells in collagen type I-based recombinant peptide scaffolds. In: J Biomed Mater Res A. vol. 105A, 29 March 2017 edn; 2017: 11.
  • Schürlein S, Al Hijailan R, Weigel T, Kadari A, Rücker C, Edenhofer F, Walles H, Hansmann J:
    Generation of a Human Cardiac Patch Based on a Reendothelialized Biological Scaffold (BioVaSc). In: Advanced Biosystems. vol. 1; 2017: n/a-n/a.
  • Seher A, Lagler C, Stuhmer T, Muller-Richter UDA, Kubler AC, Sebald W, Muller TD, Nickel J:
    Utilizing BMP-2 muteins for treatment of multiple myeloma. In: PLoS One. vol. 12, 2017/05/11 edn; 2017: e0174884.
  • Tabisz B, Schmitz W, Schmitz M, Luehmann T, Heusler E, Rybak JC, Meinel L, Fiebig JE, Mueller TD, Nickel J:
    Site-Directed Immobilization of BMP-2: Two Approaches for the Production of Innovative Osteoinductive Scaffolds. In: Biomacromolecules. vol. 18, 2017/02/18 edn; 2017: 695-708.

2016

  • Antje Appelt-Menzel and Ivo Schwedhelm FK, Alevtina Cubukova, Frank Edenhofer, Heike Walles, Jan Hansmann:
    Evaluation of various bioreactor process systems for the production of induced pluripotent stem cells. In: Journal of Translational Science. 2016.
  • Appelt-Menzel A NW, Cubukova A, Wilhelm A,Günther K, Edenhofer F, Piontek J, Krause G, Stüber T, Walles H, Metzger M:
    Establishment of a human blood-brain barrier co-culture model mimicking the neurovascular unit using induced pluripotent and multipotent stem cells. In: Stem Cell Reports. vol. in revision; 2016.
  • Brendtke R, Wiehl M, Sening W, Groeber F, Schwarz T, Walles W, Hansmann J:
    Feasibility Study on a Microwave-Based Sensor for Measuring Hydration Level Using Human Skin Models. In: PlosONE. 2016.
  • Fecher D, Hofmann E, Buck A, Bundschuh R, Nietzer S, Dandekar G, Walles T, Walles H, Luckerath K, Steinke M:
    Human Organotypic Lung Tumor Models: Suitable For Preclinical 18F-FDG PET-Imaging. In: PLoS One. vol. 11; 2016: e0160282.
  • Göttlich C ML, Kunz M, Schmitt F, Walles H, Walles T, Dandekar T, Dandekar G, Nietzer SL:
    A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds. In: J Vis Exp. 2016: e53885.
  • Groeber F, Engelhardt L, Lange J, Kurdyn S, Schmid FF, Rücker C, Mielke S, Walles H, Hansmann J:
    A first vascularized skin equivalent for as an alternative to animal experimentation. In: ALTEX. 2016.
  • Haider D, Gilbert DF, Malhotra D, Limmer A, Engelhardt H, Amtmann A, Hansmann J, Hübner H, Buchholz R, Friedrich O et al:
    Measuring average rheological quantities of cell monolayers in the linear viscoelastic regime. In: Rheologica Acta. 2016.
  • Jannasch M, Weigel T, Engelhardt L, Wiezoreck J, Gaetzner S, Walles H, Schmitz T, Hansmann J:
    In vitro chemotaxis and tissue remodeling assays quantitatively characterize foreign body reaction. In: ALTEX. 2016.
  • Katharina Gunther and Antje Appelt-Menzel CKK, Heike Walles, Marco Metzger and Frank Edenhofer:
    Rapid Monolayer Neural Induction of induced Pluripotent Stem Cells Yields Stably Proliferating Neural Stem Cells. In: Journal of Stem Cell Research & Therapy. 2016.
  • Kilian T, Fidler F, Kasten A, Nietzer S, Landgraf V, Weiss K, Walles H, Westphal F, Hackenberg S, Gruttner C et al:
    Stem cell labeling with iron oxide nanoparticles: impact of 3D culture on cell labeling maintenance. In: Nanomedicine (Lond). 2016.
  • Lotz C, Schmid FF, Rossi A, Kurdyn S, Kampik D, De Wever B, Walles H, Groeber FK:
    Alternative methods for the replacement of eye irritation testing. In: ALTEX. vol. 33; 2016: 55-67.
  • Nietzer S, Baur F, Sieber S, Hansmann J, Schwarz T, Stoffer C, Häfner H, Gasser M, Waaga-Gasser AM, Walles H et al:
    Mimicking metastases including tumor stroma: a new technique to generate a 3D colorectal cancer model based on a biological decellularized intestinal scaffold. In: Tissue Engineering, Part C: Methods. 03.05.2016 edn; 2016.
  • Pers YM, Rackwitz L, Ferreira R, Pullig O, Delfour C, Barry F, Sensebe L, Casteilla L, Fleury S, Bourin P et al:
    Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial. In: Stem Cells Transl Med. vol. 5; 2016: 847-856.
  • Rosenbaum C, Schick MA, Wollborn J, Heider A, Scholz CJ, Cecil A, Niesler B, Hirrlinger J, Walles H, Metzger M:
    Activation of Myenteric Glia during Acute Inflammation In Vitro and In Vivo. In: PLoS One. vol. 11, 2016/03/11 edn; 2016: e0151335.
  • Rossi A, L. W, K.H. H, Walles H, J. G:
    Isotropic versus bipolar functionalized biomimetic artificial basement membranes and their evaluation in long term human cell co-culture. In: Advanced Healthcare Materials. 2016.
  • Rücker C, Kirch H, Pullig O, Walles H:
    Strategies and First Advances in the Development of Prevascularized Bone Implants. In: Current Molecular Biology Reports. 2016: 1-9.
  • Schuerlein S, Schwarz T, Krziminski S, Gatzner S, Hoppensack A, Schwedhelm I, Schweinlin M, Walles H, Hansmann J:
    A versatile modular bioreactor platform for Tissue Engineering. In: Biotechnol J. 2016.
  • Schweinlin M, Rossi A, Lodes N, Lotz C, Hackenberg S, Steinke M, Walles H, Groeber F:
    Human barrier models for the in vitro assessment of drug delivery. In: Drug Deliv Transl Res. 2016.
  • Suliman S, Mustafa K, Krueger A, Steinmuller-Nethl D, Finne-Wistrand A, Osdal T, Hamza AO, Sun Y, Parajuli H, Waag T et al:
    Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes. In: Biomaterials. vol. 95, 2016/04/25 edn; 2016: 11-21.
  • Suliman S, Sun Y, Pedersen TO, Xue Y, Nickel J, Waag T, Finne-Wistrand A, Steinmuller-Nethl D, Krueger A, Costea DE et al:
    In Vivo Host Response and Degradation of Copolymer Scaffolds Functionalized with Nanodiamonds and Bone Morphogenetic Protein 2. In: Adv Healthc Mater. vol. 5, 2016/02/09 edn; 2016: 730-742.
  • Szczerba W, Zukrowski J, Przybylski M, Sikora M, Safonova O, Shmeliov A, Nicolosi V, Schneider M, Granath T, Oppmann M et al:
    Pushing up the magnetisation values for iron oxide nanoparticles via zinc doping: X-ray studies on the particle's sub-nano structure of different synthesis routes. In: Physical Chemistry Chemical Physics. vol. 18: The Royal Society of Chemistry; 2016: 25221-25229.

2015

  • Appelt-Menzel A, Rossi A, Kurdyn S, Walles H, Groeber F:
    Generation of a three-dimensional full thickness skin equivalent and automated wounding. In: JoVE. vol. J Vis Exp. 2015 Feb 26;(96). doi: 10.3791/52576. PMID: 25741763 2015.
  • Baleeiro RB SM, Rietscher R, Diedrich A,Czaplewska JA, Metzger M, Lehr CM Scherließ R, Hanefeld H, Gottschaldt M, Walden P:
    Nanoparticle-based mucosal vaccines targeting tumor associated antigens to human dendritic cells. In: Journal of Biomedical nanotechnology. vol. 12; 2015: 1527 - 1543.
  • Belka J, Weigel T, Berninger AK, Kurth D, Nickel J:
    Growth and Differentiation of Myoblastic Precursor Cells on Thin Films of Metallo-Supramolecular Coordination Polyelectrolyte (MEPE). In: ACS Applied Materials & Interfaces vol. submitted; 2015.
  • Brendtke R:
    Von der Entwicklung bis zur Zertifizierung. In: MEDengineering. 2015: 50-51.
  • Brendtke R, Wiehl M, Walles H, Hansmann J:
    Personalized medicine and health monitoring with focus on hydration to improve healthcare systems in context of demographic changes. In: British Journal of Health Informatics and Monitoring. vol. 2; 2015: 11-30.
  • Fidler F, Steinke M, Kraupner A, Grüttner C, Hiller K, Briel A, Westphal F, Walles H, Jakob P:
    Stem Cell Vitality Assessment Using Magnetic Particle Spectroscopy. In: IEEE Transactions on Magnetics. vol. 51; 2015.
  • Hinderer S, Shena N, Ringuette LJ, Hansmann J, Reinhardt DP, Brucker SY, Davis EC, Schenke-Layland K:
    In vitro elastogenesis: instructing human vascular smooth muscle cells to generate an elastic fiber-containing extracellular matrix scaffold. In: Biomed Mater. vol. 10; 2015: 034102.
  • Jannasch M, Groeber F, Brattig NW, Unger C, Walles H, Hansmann J:
    Development and application of three-dimensional skin equivalents for the investigation of percutaneous worm invasion. In: Exp Parasitol. vol. 150; 2015: 22-30.
  • Klammert U, Mueller TD, Hellmann TV, Wuerzler KK, Kotzsch A, Schliermann A, Schmitz W, Kuebler AC, Sebald W, Nickel J:
    GDF-5 can act as a context-dependent BMP-2 antagonist. In: BMC Biol. vol. 13, 2015/09/20 edn; 2015: 77.
  • Kleinhans C, Mohan RR, Vacun G, Schwarz T, Haller B, Sun Y, Kahlig A, Kluger P, Finne-Wistrand A, Walles H et al:
    A perfusion bioreactor system efficiently generates cell-loaded bone substitute materials for addressing critical size bone defects. In: Biotechnol J. 2015.
  • Lühmann T, Jones G, Gutmann M, Rybak JC, Nickel J, Rubini M, Meinel L:
    Bio-orthogonal immobilization of fibroblast growth factor 2 for spatial controlled cell proliferation. In: ACS Biomaterials Science & Engineering. vol. in press; 2015.
  • M J, F G, NW B, C U, H W, J H:
    Development and application of three-dimensional skin equivalents for the investigation of percutaneous worm invasion. In: Experimental Parasitology vol. 150, 2015 Jan 12 edn; 2015: 22-30.
  • Meir M, Flemming S, Burkard N, Bergauer L, Metzger M, Germer CT, Schlegel N:
    Glial cell line-derived neurotrophic factor (GDNF) promotes barrier maturation and wound healing in intestinal epithelial cells in vitro. In: Am J Physiol Gastrointest Liver Physiol. 2015: ajpgi 00357 02014.
  • Rossi A, Appelt-Menzel A, Kurdyn S, Walles H, Groeber F:
    Generation of a three-dimensional full thickness skin equivalent and automated wounding. In: J Vis Exp. 2015.
  • Schacht K. JT, Schweinlin M., Ewald A., Groll J., Scheibel T.:
    Biofabrication of cell-loaded 3D spider silk constructs. In: Angew Chem Int Ed Engl vol. 54; 2015: 2816-2820.
  • Schmid F, Schwarz T, Schuberthan W, Klos M, Walles H, Hansmann J, Groeber F:
    Applicability of a Dual-Arm Robotic System for Automated Downstream Analysis of Epidermal Model. In: Applied In Vitro Toxicology. 2015.
  • Suliman S, Xing Z, Wu X, Xue Y, Pedersen TO, Sun Y, Doskeland AP, Nickel J, Waag T, Lygre H et al:
    Release and bioactivity of bone morphogenetic protein-2 are affected by scaffold binding techniques in vitro and in vivo. In: J Control Release. vol. 197, 2014/12/03 edn; 2015: 148-157.
  • T. S-Y, Rossi A, K.H. H, F. P, J. G, MJ. B-P:
    Neuregulin encapsulation and biocompatibility studies in a model of myocardial ischemia. In: Tissue Engineering Part A. 2015.

2014

  • Alepee N, Bahinski T, Daneshian M, De Wever B, Fritsche E, Goldberg A, Hansmann J, Hartung T, Haycock J, Hogberg H et al:
    State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. In: ALTEX. vol. 31; 2014: 441-477.
  • Delling U BW, Metzger M, Ludewig E, Winter K, Jülke H.:
    In vivo tracking and fate of intraarticularly injected superparamagnetic iron oxide particle-labeled multipotent stromal cells in an ovine model of osteoarthritis. In: Cell Transplantation. vol. DEC 2014; 2014.
  • Groeber F, Engelhardt L, Egger S, Werthmann H, Monaghan M, Walles H, Hansmann J:
    Impedance Spectroscopy for the Non-Destructive Evaluation of In Vitro Epidermal Models. In: Pharm Res. 2014.
  • Heinlein A MM, Walles H, Buettner A.:
    Transport of hop aroma compounds across Caco-2 monolayers. In: Food Funct. 2014: 2719-2730.
  • Hetz S, Acikgoez A, Moll C, Jahnke H-G, Robitzki AA, Metzger R, Metzger M:
    Age-related gene expression analysis in enteric ganglia of human colon after laser microdissection. In: Frontiers in Aging Neuroscience. vol. 6; 2014.
  • Hetz S, Acikgoez A, Voss U, Nieber K, Holland H, Hegewald C, Till H, Metzger R, Metzger M:
    In vivo transplantation of neurosphere-like bodies derived from the human postnatal and adult enteric nervous system: a pilot study. In: PloS One vol. 9; 2014.
  • Hetz S, Acikgoez A, Voss U, Nieber K, Holland H, Hegewald C, Till H, Metzger R, Metzger M:
    In vivo transplantation of neurosphere-like bodies derived from the human postnatal and adult enteric nervous system: a pilot study. In: PLoS One. vol. 9; 2014: e93605.
  • Hetz S AA, Moll C, Jahnke HG, Robitzki AA, Metzger R, Metzger M:
    Age related analysis of enteric ganglia of human colon using laser microdissection. In: Front Neuroscience. vol. 15; 2014: 276.
  • Hetz S AA, Voss U, Nieber K, Holland H, Hegewald C, Till H, Metzger R, Metzger M:
    In vivo transplantation of neurosphere-like bodies derived from the human postnatal and adult enteric nervous system: a pilot study. In: PloS One. vol. 9; 2014: e93605.
  • Markenstein L, Appelt-Menzel A, Metzger M, Wenz G:
    Conjugates of methylated cyclodextrin derivatives and hydroxyethyl starch (HES): Synthesis, cytotoxicity and inclusion of anaesthetic actives. In: Beilstein J Org Chem. vol. Beilstein J. Org. Chem. 2014, 10, 3087–3096. doi:10.3762/bjoc.10.325; 2014.
  • Raeth S, Sacchetti B, Siegel G, Mau-Holzmann UA, Hansmann J, Vacun G, Hauk TG, Pfizenmaier K, Hausser A:
    A mouse bone marrow stromal cell line with skeletal stem cell characteristics to study osteogenesis in vitro and in vivo. In: Stem Cells Dev. vol. 23; 2014: 1097-1108.
  • Rossi A, Fecher D, Egner S, Schweinlin M, Steinke M:
    Humane 3D-in vitro-Testsysteme für die präklinische Forschung. In: Biospektrum. vol. 04.14; 2014.
  • Steinke M, Dally I, Friedel G, Walles H, Walles T:
    Host-integration of a tissue-engineered airway patch: 2-year follow-up in a single patient. In: Tissue Eng Part A. vol. 21; 2014.
  • Steinke M, Gross R, Walles H, Gangnus R, Schutze K, Walles T:
    An engineered 3D human airway mucosa model based on an SIS scaffold. In: Biomaterials. vol. 35; 2014: 7355-7362.
  • Stratmann AT FD, Wangorsch G, Göttlich C, Walles T, Walles H, Dandekar T, Dandekar G, Nietzer SL:
    Establishment of a human 3D lung cancer model based on a biological tissue matrix combined with a Boolean in silico model. In: Molecular Oncology. vol. 8; 2014: 351-365.
  • Zeplin PH, Berninger AK, Maksimovikj NC, van Gelder P, Scheibel T, Walles H:
    Verbesserung der Biokompatibilität von Silikonimplantaten durch Spinnenseidenbeschichtung: Immunhistochemische Untersuchungen zum Einfluss auf die Kapselbildung. In: Handchir Mikrochir plast Chir. vol. 46, 08.12.2014 edn; 2014: 336-341.
  • Zeplin PH, Maksimovikj NC, Jordan MC, Nickel J, Lang G, Leimer AH, Roemer L, Scheibel T:
    Spider Silk Coatings as a Bioshield to Reduce Periprosthetic Fibrous Capsule Formation. In: Advanced Functional Materials. vol. 24; 2014: 2658-2666.