Publications

• Lotz C., Kiesewetter L., Schmid F.F., Hansmann, J., Walles H. & Groeber-Becker F.:
  Replacing the Draize eye test: Impedance spectroscopy as a 3R method to discriminate between all GHS categories for eye irritation.

Das Augenlicht ist einer unserer wertvollsten Sinne. Um unsere Augen vor schädlichen Substanzen zu schützen, müssen chemische Stoffe in Bezug auf ihr Schädigungspotenzial getestet werden. Eine Standardmethode dafür ist der Draize-Test, bei dem Kaninchen in Tierversuchen eingesetzt werden. Das Translationszentrum Regenerative Therapien hat eine Alternative entwickelt, die ohne Tierversuche auskommt. Die neue Methode basiert auf einem In-vitro-Testmodell der menschlichen Cornea/Augenhornhaut und einem zerstörungsfreien Messsystem. Diese Kombination ermöglicht die Bewertung und Einordnung von Substanzen in die drei Kategorien des international standardisierten Klassifikationssystems der Augenreizungen mit hoher Genauigkeit und Zuverlässigkeit mit einem In-vitro-Test. Damit könnte der Draize-Test ersetzt werden, gemäß dem 3R Prinzip zur Verringerung von Tierversuchen.

>> Hier gelangen Sie zum vollständigen Artikel über »Replacing the Draize eye test: Impedance spectroscopy as a 3R method to discriminate between all GHS categories for eye irritation« 

• Berger C., Bjorlykke Y., Muhlemann M., Raeder H., Walles H., Metzger M., Zdzieblo D.:
  A pancreas-specific ECM scaffold – human iPS cell culture and pancreatic differentiation goes 3D. Diabetologia 2018, 61: S.192-S.192.
• Burghartz M., Lennartz S., Schweinlin M., Hagen R., Kleinsasser N., Hackenberg S., Steussloff G., Scherzad A., Radeloff K., Ginzkey C. et al.:
  Development of Human Salivary Gland-Like Tissue In Vitro. Tissue Eng Part A 2018, 24 (3-4): 301-309.
• Chen MJ., Whiteley JP., Please CP., Schwab A., Ehlicke F., Waters SL., Byrne HM.:
  Inducing chondrogenesis in MSC/chondrocyte co-cultures using exogenous TGF-beta: a mathematical model. J Theor Biol 2018, 439: 1-13.
• Confalonieri D., Schwab A., Walles H., Ehlicke F.: Advanced Therapy Medicinal Products:
  A Guide for Bone Marrow-derived MSC Application in Bone and Cartilage Tissue Engineering. Tissue Eng Part B-Rev 2018, 24(2): 155-169.
• Ditgen D., Anandarajah EM., Reinhardt A., Younis AE., Witt S., Hansmann J., Lorenz E., Garcia-Hernandez M., Paclik D., Soblik H. et al:
  Comparative characterization of two galectins excreted-secreted from intestine-dwelling parasitic versus free-living females of the soil-transmitted nematode Strongyloides. Mol Biochem Parasitol 2018, 225: 73-83.
• Gottlich C., Kunz M., Zapp C., Nietzer SL., Walles H., Dandekar T., Dandekar G.:
  A combined tissue-engineered/insilico signature tool patient stratification in lung cancer. Mol Oncol 2018, 12(8): 1264-1285.
• Hafen B., Wiesner S., Schlegelmilch K., Keller A., Seefried L., Ebert R., Walles H., Jakob F., Schutze N.:
  Physical contact between mesenchymal stem cells and endothelial precursors induces distinct signatures with relevance to the very early phase of regeneration. J Cell Biochem 2018, 119(11): 9122-9140.
• Kress S., Baur J., Otto C., Burkard N., Braspenning J., Walles H., Nickel J., Metzger M.:
  Evaluation of a Miniaturized Biologically Vascularized Scaffold in vitro and in vivo. Sci Rep 2018, 8:13.
• Lohr D., Terekhov M., Weng AM., Schroeder A., Walles H., Schreiber LM.:
  Possible benefits of ultra high field MRI in cardiac diffusion tensor imaging. Eur J Heart Fail 2018, 20: 149-150
• Lotz C., Kiesewetter L., Schmid FF., Hansmann J., Walles H., Groeber-Becker F.:
  Replacing the Draize eye test: Impedance spectroscopy as a 3R method to discriminate between all GHS categories for eye irritation. Sci Rep 2018, 8:13.
• Massie I., Spaniol K., Barbian A., Geerling G., Metzger M., Schrader S.:
  Development of lacrimal gland spheroids for lacrimal gland tissue regeneration. J Tissue Eng Regen Med 2018, 12(4): E2001-E2009.
• Muhlemann M., Zdzieblo D., Friedrich A., Berger C., Otto C., Walles H., Koepsell H., Metzger M.:
  Altered pancreatic islet morphology and function in SGLT1 knockout mice on a glucose-deficient, fat-enriched diet. Mol Metab 2018, 13: 67-76.
• Mumcuoglu D., de Miguel L., Jekhmane S., Siverino C., Nickel J., Mueller TD., van Leeuwen JP., van Osch GJ., Kluijtmans SG.:
  Collagen I derived recombinant protein microspheres as novel delivery vehicles for bone morphogenetic protein-2. Mater Sci Eng C-Mater Biol Appl 2018, 84: 271-280.
• Munoz MS., Confalonieri D., Walles H., van Dongen E., Dandekar G.:
  Recombinant Collagen I Peptide Microcarriers for Cell Expansion and Their Potential Use As Cell Delivery System in a Bioreactor Model. J Vis Exp 2018(132): 11.
• Nickel J., ten Dijke P., Mueller TD.:
  TGF-beta family co-receptor function and signaling. Acta Biochim Biophys Sin 2018, 50(1): 12-36.
• Olgasi C., Merlin S., Bittorf P., Mazzuca D., Stolzing A., Toleikidis P., Zierau M., Follenzi A., Braspenning J., Bergmann T.:
  HemAcure: Application of combined gene and cell therapy within an implantable therapeutic device for the treatment of severe haemophilia A. Haemophilia 2018, 24: 66-66.
• Olgasi C., Merlin S., Borsotti C., Bergmann T., Mazzucca DM., Stolzing A., Zierau M., Toleikis PM., Braspenning J., Follenzi A.:
  Application of combined gene and cell therapy within an implantable therapeutic device for the treatment of severe haemophilia A. Hum Gene Ther 2018, 29(12): A61-A61.
• Pali M., Terekhov M., Wittke C., Wagner N., Schroeder A., Walles H., Erguen S., Zernecke-Madsen A., Schreiber LM.:
  High-Resolution and Semidynamic Vessel Wall Imaging Kinetics obtained from Stable Radical MRI in ex-vivo Porcine Aorta. Eur J Heart Fail 2018, 20: 522-523.
• Pers YM., Quentin J., Feirreira R., Espinoza F., Abdellaoui N., Erkilic N., Dufourcq-Lopez E., Pullig O., Noth U., Jorgensen C. et al.:
  Injection of Adipose-Derived Stromal Cells in the Knee of Patients with Severe Osteoarthritis has a Systemic Effect and Promotes an Anti-Inflammatory Phenotype of Circulating Immune Cells. Theranostics 2018, 8(20): 5519-5528.
• Ramani-Mohan RK., Schwedhelm I., Finne-Wistrand A., Krug M., Schwarz T., Jakob F., Walles H., Hansmann J.:
  Deformation strain is the main physical driver for skeletal precursors to undergo osteogenesis in earlier stages of osteogenic cell maturation. J Tissue Eng Regen Med 2018, 12(3): E1474-E1479.
• Ribitsch I., Peham C., Ade N., Durr J., Handschuh S., Schramel JP., Vogl C., Walles H., Egerbacher M., Jenner F.:
  Structure-Function relationships of equine menisci. PLoS One 2018, 13(3): 17.
• Schellenberger MT., Bock U., Hennen J., Grober-Becker F., Walles H., Blomeke B.:
  An in vitro coculture system composed of THP-1 cells and 3D reconstructed human epidermis to assess activation of dendritic cells by sensitizing chemicals. Naunyn-Schmiedebergs Arch Pharmacol 2018, 391: S.49-S.49.
• Schellenberger MT., Bock U., Hennen J., Groeber-Becker F., Wailes H., Blomeke B.:
  The use of a THP-1/3D reconstructed human epidermis (RHE) coculture system to assess the sensitizing potential of chemicals. Toxicol Lett 2018, 295: S.161-S.162.
• Schliermann A., Nickel J.:
  Unraveling the Connection between Fibroblast Growth Factor and Bone Morphogenetic Protein Signaling. Int J Mol Sci 2018, 19(10): 17.
• Schmid FF., Groeber-Becker F., Schwab S., Thude S., Goebeler M., Walles H., Hansmann J.:
  A Standardized Method Based on Pigmented Epidermal Models Evaluates Sensitivity Against UV-Irradiation. ALTEX-Altern Anim Exp 2018, 35(3): 390-396.
• Schmid R, Tarau IS, Rossi A, Leonhardt S, Schwarz T., Schuerlein S., Lotz C., Hansmann J.:
  In Vivo-Like Culture Conditions in a Bioreactor Facilitate Improved Tissue Quality in Corneal Storage. Biotechnol J 2018, 13(1): 7.
• Siverino C., Tabisz B., Luhmann T., Meinel L., Muller T., Walles H., Nickel J.:
  Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry. J Vis Exp 2018(133): 8.
• Steinke M., Zunhammer F., Chatzopoulou EI., Teller H., Schutze K., Walles H., Radler JO., Gruttner C.:
  Rapid Analysis of Cell-Nanoparticle Interactions using Single-Cell Raman Trapping Microscopy. Angew Chem-Int Edit 2018, 57(18): 4946-4950.
• Stuckensen K., Schwab A., Knauer M., Muinos-Lopez E., Ehlicke F., Reboredo J., Granero-Molto F., Gbureck U., Prosper F., Walles H. et al.:
  Tissue Mimicry in Morphology and Composition Promotes Hierarchical Matrix Remodeling of Invading Stem Cells in Osteochondral and Meniscus Scaffolds. Adv Mater 2018, 30(28): 7.
• Weigel T., Schmitz T., Pfister T., Gaetzner S., Jannasch M., Al-Hijailan R., Schurlein S., Suliman S., Mustafa K., Hansmann J.:
  A three-dimensional hybrid pacemaker electrode seamlessly integrates into engineered, functional human cardiac tissue in vitro. Sci Rep 2018, 8:13.
• Wintzheimer S., Szczerba W., Buzanich AG., Kashiwaya S., Klein A., Jaegermann W., Toupance T., Shmeliov A., Nicolosi V., Heuze K. et al.:
  Discovering the Determining Parameters for the Photocatalytic Activity of TiO2 Colloids Based on an Anomalous Dependence on the Specific Surface Area. Part Part Syst Charact 2018, 35(9): 10.

• Belka J, Weigel T, Berninger AK, Kurth DG, Nickel J:
  Growth and Differentiation of Myoblastic Precursor Cells on Thin Films of Metallo-Supramolecular Coordination Polyelectrolyte (MEPE). In: Advanced Materials Interfaces. vol. 4; 2017.
• Confalonieri D, La Marca M, van Dongen EMWM, Walles H, Ehlicke F:
  An Injectable Recombinant Collagen I Peptide-Based Macroporous Microcarrier Allows Superior Expansion of C2C12 and Human Bone Marrow-Derived Mesenchymal Stromal Cells and Supports Deposition of Mineralized Matrix. In: Tissue Eng Part A. 2017: 12.
• Christ B FC, Cubukova A, Walles H, Dembski S, Metzger M:
  Screening applications to test cellular fitness in Transwell(r) models after nanoparticle treatment. In: Methods in Molecular Biology. vol. 1601; 2017: 111-122.
• Kimpton LS, Schwab A, Ehlicke F, Waters SL, Please CP, Whiteley JP, Byrne HM:
  A mathematical model for cell infiltration and proliferation in a chondral defect. In: Math Biosci. vol. 292; 2017: 46-56.
• Lagler C, El-Mesery M, Kubler AC, Muller-Richter UDA, Stuhmer T, Nickel J, Muller TD, Wajant H, Seher A:
  The anti-myeloma activity of bone morphogenetic protein 2 predominantly relies on the induction of growth arrest and is apoptosis-independent. In: PLoS One. vol. 12, 2017/10/14 edn; 2017: e0185720
• Nickel J, Ten Dijke P, Mueller TD:
  TGF-beta family co-receptor function and signaling. In: Acta Biochim Biophys Sin (Shanghai). 2018/01/03 edn; 2017.
• Pawelec KM, Confalonieri D, Ehlicke F, van Boxtel HA, Walles H, Kluijtmans SGJM:
  Osteogenesis and mineralization of mesenchymal stem cells in collagen type I-based recombinant peptide scaffolds. In: J Biomed Mater Res A. vol. 105A, 29 March 2017 edn; 2017: 11.
• Schürlein S, Al Hijailan R, Weigel T, Kadari A, Rücker C, Edenhofer F, Walles H, Hansmann J:
  Generation of a Human Cardiac Patch Based on a Reendothelialized Biological Scaffold (BioVaSc). In: Advanced Biosystems. vol. 1; 2017: n/a-n/a.
• Seher A, Lagler C, Stuhmer T, Muller-Richter UDA, Kubler AC, Sebald W, Muller TD, Nickel J:
  Utilizing BMP-2 muteins for treatment of multiple myeloma. In: PLoS One. vol. 12, 2017/05/11 edn; 2017: e0174884.
• Tabisz B, Schmitz W, Schmitz M, Luehmann T, Heusler E, Rybak JC, Meinel L, Fiebig JE, Mueller TD, Nickel J:
  Site-Directed Immobilization of BMP-2: Two Approaches for the Production of Innovative Osteoinductive Scaffolds. In: Biomacromolecules. vol. 18, 2017/02/18 edn; 2017: 695-708.

• Antje Appelt-Menzel and Ivo Schwedhelm FK, Alevtina Cubukova, Frank Edenhofer, Heike Walles, Jan Hansmann:
  Evaluation of various bioreactor process systems for the production of induced pluripotent stem cells. In: Journal of Translational Science. 2016.
• Appelt-Menzel A NW, Cubukova A, Wilhelm A,Günther K, Edenhofer F, Piontek J, Krause G, Stüber T, Walles H, Metzger M:
  Establishment of a human blood-brain barrier co-culture model mimicking the neurovascular unit using induced pluripotent and multipotent stem cells. In: Stem Cell Reports. vol. in revision; 2016.
• Brendtke R, Wiehl M, Sening W, Groeber F, Schwarz T, Walles W, Hansmann J:
  Feasibility Study on a Microwave-Based Sensor for Measuring Hydration Level Using Human Skin Models. In: PlosONE. 2016.
• Fecher D, Hofmann E, Buck A, Bundschuh R, Nietzer S, Dandekar G, Walles T, Walles H, Luckerath K, Steinke M:
  Human Organotypic Lung Tumor Models: Suitable For Preclinical 18F-FDG PET-Imaging. In: PLoS One. vol. 11; 2016: e0160282.
• Göttlich C ML, Kunz M, Schmitt F, Walles H, Walles T, Dandekar T, Dandekar G, Nietzer SL:
  A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds. In: J Vis Exp. 2016: e53885.
• Groeber F, Engelhardt L, Lange J, Kurdyn S, Schmid FF, Rücker C, Mielke S, Walles H, Hansmann J:
  A first vascularized skin equivalent for as an alternative to animal experimentation. In: ALTEX. 2016.
• Haider D, Gilbert DF, Malhotra D, Limmer A, Engelhardt H, Amtmann A, Hansmann J, Hübner H, Buchholz R, Friedrich O et al:
  Measuring average rheological quantities of cell monolayers in the linear viscoelastic regime. In: Rheologica Acta. 2016.
• Jannasch M, Weigel T, Engelhardt L, Wiezoreck J, Gaetzner S, Walles H, Schmitz T, Hansmann J:
  In vitro chemotaxis and tissue remodeling assays quantitatively characterize foreign body reaction. In: ALTEX. 2016.
• Katharina Gunther and Antje Appelt-Menzel CKK, Heike Walles, Marco Metzger and Frank Edenhofer:
  Rapid Monolayer Neural Induction of induced Pluripotent Stem Cells Yields Stably Proliferating Neural Stem Cells. In: Journal of Stem Cell Research & Therapy. 2016.
• Kilian T, Fidler F, Kasten A, Nietzer S, Landgraf V, Weiss K, Walles H, Westphal F, Hackenberg S, Gruttner C et al:
  Stem cell labeling with iron oxide nanoparticles: impact of 3D culture on cell labeling maintenance. In: Nanomedicine (Lond). 2016.
• Lotz C, Schmid FF, Rossi A, Kurdyn S, Kampik D, De Wever B, Walles H, Groeber FK:
  Alternative methods for the replacement of eye irritation testing. In: ALTEX. vol. 33; 2016: 55-67.
• Nietzer S, Baur F, Sieber S, Hansmann J, Schwarz T, Stoffer C, Häfner H, Gasser M, Waaga-Gasser AM, Walles H et al:
  Mimicking metastases including tumor stroma: a new technique to generate a 3D colorectal cancer model based on a biological decellularized intestinal scaffold. In: Tissue Engineering, Part C: Methods. 03.05.2016 edn; 2016.
• Pers YM, Rackwitz L, Ferreira R, Pullig O, Delfour C, Barry F, Sensebe L, Casteilla L, Fleury S, Bourin P et al:
  Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial. In: Stem Cells Transl Med. vol. 5; 2016: 847-856.
• Rosenbaum C, Schick MA, Wollborn J, Heider A, Scholz CJ, Cecil A, Niesler B, Hirrlinger J, Walles H, Metzger M:
  Activation of Myenteric Glia during Acute Inflammation In Vitro and In Vivo. In: PLoS One. vol. 11, 2016/03/11 edn; 2016: e0151335.
• Rossi A, L. W, K.H. H, Walles H, J. G:
  Isotropic versus bipolar functionalized biomimetic artificial basement membranes and their evaluation in long term human cell co-culture. In: Advanced Healthcare Materials. 2016.
• Rücker C, Kirch H, Pullig O, Walles H:
  Strategies and First Advances in the Development of Prevascularized Bone Implants. In: Current Molecular Biology Reports. 2016: 1-9.
• Schuerlein S, Schwarz T, Krziminski S, Gatzner S, Hoppensack A, Schwedhelm I, Schweinlin M, Walles H, Hansmann J:
  A versatile modular bioreactor platform for Tissue Engineering. In: Biotechnol J. 2016.
• Schweinlin M, Rossi A, Lodes N, Lotz C, Hackenberg S, Steinke M, Walles H, Groeber F:
  Human barrier models for the in vitro assessment of drug delivery. In: Drug Deliv Transl Res. 2016.
• Suliman S, Mustafa K, Krueger A, Steinmuller-Nethl D, Finne-Wistrand A, Osdal T, Hamza AO, Sun Y, Parajuli H, Waag T et al:
  Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes. In: Biomaterials. vol. 95, 2016/04/25 edn; 2016: 11-21.
• Suliman S, Sun Y, Pedersen TO, Xue Y, Nickel J, Waag T, Finne-Wistrand A, Steinmuller-Nethl D, Krueger A, Costea DE et al:
  In Vivo Host Response and Degradation of Copolymer Scaffolds Functionalized with Nanodiamonds and Bone Morphogenetic Protein 2. In: Adv Healthc Mater. vol. 5, 2016/02/09 edn; 2016: 730-742.
• Szczerba W, Zukrowski J, Przybylski M, Sikora M, Safonova O, Shmeliov A, Nicolosi V, Schneider M, Granath T, Oppmann M et al:
  Pushing up the magnetisation values for iron oxide nanoparticles via zinc doping: X-ray studies on the particle's sub-nano structure of different synthesis routes. In: Physical Chemistry Chemical Physics. vol. 18: The Royal Society of Chemistry; 2016: 25221-25229.

• Appelt-Menzel A, Rossi A, Kurdyn S, Walles H, Groeber F:
  Generation of a three-dimensional full thickness skin equivalent and automated wounding. In: JoVE. vol. J Vis Exp. 2015 Feb 26;(96). doi: 10.3791/52576. PMID: 25741763 2015.
• Baleeiro RB SM, Rietscher R, Diedrich A,Czaplewska JA, Metzger M, Lehr CM Scherließ R, Hanefeld H, Gottschaldt M, Walden P:
  Nanoparticle-based mucosal vaccines targeting tumor associated antigens to human dendritic cells. In: Journal of Biomedical nanotechnology. vol. 12; 2015: 1527 - 1543.
• Belka J, Weigel T, Berninger AK, Kurth D, Nickel J:
  Growth and Differentiation of Myoblastic Precursor Cells on Thin Films of Metallo-Supramolecular Coordination Polyelectrolyte (MEPE). In: ACS Applied Materials & Interfaces vol. submitted; 2015.
• Brendtke R:
  Von der Entwicklung bis zur Zertifizierung. In: MEDengineering. 2015: 50-51.
• Brendtke R, Wiehl M, Walles H, Hansmann J:
  Personalized medicine and health monitoring with focus on hydration to improve healthcare systems in context of demographic changes. In: British Journal of Health Informatics and Monitoring. vol. 2; 2015: 11-30.
• Fidler F, Steinke M, Kraupner A, Grüttner C, Hiller K, Briel A, Westphal F, Walles H, Jakob P:
  Stem Cell Vitality Assessment Using Magnetic Particle Spectroscopy. In: IEEE Transactions on Magnetics. vol. 51; 2015.
• Hinderer S, Shena N, Ringuette LJ, Hansmann J, Reinhardt DP, Brucker SY, Davis EC, Schenke-Layland K:
  In vitro elastogenesis: instructing human vascular smooth muscle cells to generate an elastic fiber-containing extracellular matrix scaffold. In: Biomed Mater. vol. 10; 2015: 034102.
• Jannasch M, Groeber F, Brattig NW, Unger C, Walles H, Hansmann J:
  Development and application of three-dimensional skin equivalents for the investigation of percutaneous worm invasion. In: Exp Parasitol. vol. 150; 2015: 22-30.
• Klammert U, Mueller TD, Hellmann TV, Wuerzler KK, Kotzsch A, Schliermann A, Schmitz W, Kuebler AC, Sebald W, Nickel J:
  GDF-5 can act as a context-dependent BMP-2 antagonist. In: BMC Biol. vol. 13, 2015/09/20 edn; 2015: 77.
• Kleinhans C, Mohan RR, Vacun G, Schwarz T, Haller B, Sun Y, Kahlig A, Kluger P, Finne-Wistrand A, Walles H et al:
  A perfusion bioreactor system efficiently generates cell-loaded bone substitute materials for addressing critical size bone defects. In: Biotechnol J. 2015.
• Lühmann T, Jones G, Gutmann M, Rybak JC, Nickel J, Rubini M, Meinel L:
  Bio-orthogonal immobilization of fibroblast growth factor 2 for spatial controlled cell proliferation. In: ACS Biomaterials Science & Engineering. vol. in press; 2015.
• M J, F G, NW B, C U, H W, J H:
  Development and application of three-dimensional skin equivalents for the investigation of percutaneous worm invasion. In: Experimental Parasitology vol. 150, 2015 Jan 12 edn; 2015: 22-30.
• Meir M, Flemming S, Burkard N, Bergauer L, Metzger M, Germer CT, Schlegel N:
  Glial cell line-derived neurotrophic factor (GDNF) promotes barrier maturation and wound healing in intestinal epithelial cells in vitro. In: Am J Physiol Gastrointest Liver Physiol. 2015: ajpgi 00357 02014.
• Rossi A, Appelt-Menzel A, Kurdyn S, Walles H, Groeber F:
  Generation of a three-dimensional full thickness skin equivalent and automated wounding. In: J Vis Exp. 2015.
• Schacht K. JT, Schweinlin M., Ewald A., Groll J., Scheibel T.:
  Biofabrication of cell-loaded 3D spider silk constructs. In: Angew Chem Int Ed Engl vol. 54; 2015: 2816-2820.
• Schmid F, Schwarz T, Schuberthan W, Klos M, Walles H, Hansmann J, Groeber F:
  Applicability of a Dual-Arm Robotic System for Automated Downstream Analysis of Epidermal Model. In: Applied In Vitro Toxicology. 2015.
• Suliman S, Xing Z, Wu X, Xue Y, Pedersen TO, Sun Y, Doskeland AP, Nickel J, Waag T, Lygre H et al:
  Release and bioactivity of bone morphogenetic protein-2 are affected by scaffold binding techniques in vitro and in vivo. In: J Control Release. vol. 197, 2014/12/03 edn; 2015: 148-157.
• T. S-Y, Rossi A, K.H. H, F. P, J. G, MJ. B-P:
  Neuregulin encapsulation and biocompatibility studies in a model of myocardial ischemia. In: Tissue Engineering Part A. 2015.

• Alepee N, Bahinski T, Daneshian M, De Wever B, Fritsche E, Goldberg A, Hansmann J, Hartung T, Haycock J, Hogberg H et al:
  State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. In: ALTEX. vol. 31; 2014: 441-477.
• Delling U BW, Metzger M, Ludewig E, Winter K, Jülke H.:
  In vivo tracking and fate of intraarticularly injected superparamagnetic iron oxide particle-labeled multipotent stromal cells in an ovine model of osteoarthritis. In: Cell Transplantation. vol. DEC 2014; 2014.
• Groeber F, Engelhardt L, Egger S, Werthmann H, Monaghan M, Walles H, Hansmann J:
  Impedance Spectroscopy for the Non-Destructive Evaluation of In Vitro Epidermal Models. In: Pharm Res. 2014.
• Heinlein A MM, Walles H, Buettner A.:
  Transport of hop aroma compounds across Caco-2 monolayers. In: Food Funct. 2014: 2719-2730.
• Hetz S, Acikgoez A, Moll C, Jahnke H-G, Robitzki AA, Metzger R, Metzger M:
  Age-related gene expression analysis in enteric ganglia of human colon after laser microdissection. In: Frontiers in Aging Neuroscience. vol. 6; 2014.
• Hetz S, Acikgoez A, Voss U, Nieber K, Holland H, Hegewald C, Till H, Metzger R, Metzger M:
  In vivo transplantation of neurosphere-like bodies derived from the human postnatal and adult enteric nervous system: a pilot study. In: PloS One vol. 9; 2014.
• Hetz S, Acikgoez A, Voss U, Nieber K, Holland H, Hegewald C, Till H, Metzger R, Metzger M:
  In vivo transplantation of neurosphere-like bodies derived from the human postnatal and adult enteric nervous system: a pilot study. In: PLoS One. vol. 9; 2014: e93605.
• Hetz S AA, Moll C, Jahnke HG, Robitzki AA, Metzger R, Metzger M:
  Age related analysis of enteric ganglia of human colon using laser microdissection. In: Front Neuroscience. vol. 15; 2014: 276.
• Hetz S AA, Voss U, Nieber K, Holland H, Hegewald C, Till H, Metzger R, Metzger M:
  In vivo transplantation of neurosphere-like bodies derived from the human postnatal and adult enteric nervous system: a pilot study. In: PloS One. vol. 9; 2014: e93605.
• Markenstein L, Appelt-Menzel A, Metzger M, Wenz G:
  Conjugates of methylated cyclodextrin derivatives and hydroxyethyl starch (HES): Synthesis, cytotoxicity and inclusion of anaesthetic actives. In: Beilstein J Org Chem. vol. Beilstein J. Org. Chem. 2014, 10, 3087–3096. doi:10.3762/bjoc.10.325; 2014.
• Raeth S, Sacchetti B, Siegel G, Mau-Holzmann UA, Hansmann J, Vacun G, Hauk TG, Pfizenmaier K, Hausser A:
  A mouse bone marrow stromal cell line with skeletal stem cell characteristics to study osteogenesis in vitro and in vivo. In: Stem Cells Dev. vol. 23; 2014: 1097-1108.
• Rossi A, Fecher D, Egner S, Schweinlin M, Steinke M:
  Humane 3D-in vitro-Testsysteme für die präklinische Forschung. In: Biospektrum. vol. 04.14; 2014.
• Steinke M, Dally I, Friedel G, Walles H, Walles T:
  Host-integration of a tissue-engineered airway patch: 2-year follow-up in a single patient. In: Tissue Eng Part A. vol. 21; 2014.
• Steinke M, Gross R, Walles H, Gangnus R, Schutze K, Walles T:
  An engineered 3D human airway mucosa model based on an SIS scaffold. In: Biomaterials. vol. 35; 2014: 7355-7362.
• Stratmann AT FD, Wangorsch G, Göttlich C, Walles T, Walles H, Dandekar T, Dandekar G, Nietzer SL:
  Establishment of a human 3D lung cancer model based on a biological tissue matrix combined with a Boolean in silico model. In: Molecular Oncology. vol. 8; 2014: 351-365.
• Zeplin PH, Berninger AK, Maksimovikj NC, van Gelder P, Scheibel T, Walles H:
  Verbesserung der Biokompatibilität von Silikonimplantaten durch Spinnenseidenbeschichtung: Immunhistochemische Untersuchungen zum Einfluss auf die Kapselbildung. In: Handchir Mikrochir plast Chir. vol. 46, 08.12.2014 edn; 2014: 336-341.
• Zeplin PH, Maksimovikj NC, Jordan MC, Nickel J, Lang G, Leimer AH, Roemer L, Scheibel T:
  Spider Silk Coatings as a Bioshield to Reduce Periprosthetic Fibrous Capsule Formation. In: Advanced Functional Materials. vol. 24; 2014: 2658-2666.