Fraunhofer Translational Center Regenerative Therapies TLC-RT

The Fraunhofer Translational Center Regenerative Therapies TLC-RT develops new cell based tissue models and test systems, scalable manufacture processes, prototypes and biological vascularized implants. Therefore, besides accelerating cost efficient drug development, TLC-RT contributes to promoting the 3R principles.

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3D Bioprinting Technology

for automatized and standardized fabrication of complex living tissues

Press Release / 29.7.2022


DFG Animal Welfare Prize for the Fraunhofer Translational Center for Regenerative Therapies


Press Release / 9.8.2022

Antiviral effect of plant extracts

Proof with in vitro cell cultures successful

Analysis of the effect of plant oils

Together with its research partner Kneipp, the TLC-RT team is investigating protective as well as regenerative effects of various plant oils on in vitro skin models developed in-house. These screenings can be carried out quickly, flexibly and without animal testing.


International Symposium

»Biofabrication meets Infection«

The international symposium on the to­pics of biofabrication and complex tissue models will be held in Wuerzburg from Nov. 23-25, 2022.


Nanoparticles meet

Quality assurance, cost savings, occupational safety are only three of many aspects achieved in the automated production of nanoparticles. A dual-arm robot interacts with the surrounding laboratory infrastructure 24/7.

Dr. Sofia Dembski provides information on the fascinating future of Lab 4.0 in a case study on the APRONA prototype plant.


Felix-Wankel-Award '21

Dr. Christian Lotz (Deputy Head of Department In Vitro Test Systems) receives this year's Felix Wankel Prize for the development of an in vitro eye irritation test.

The new method is expected to replace the Draize eye test after about 80 years and thus provide an alternative to previous animal testing.

Congratulations on this success!

Fields of Activity and Teaching



  • 3D Bioprinting
  • Regenerative Biomaterials
  • In vitro and in vivo diagnostics
  • Drug Delivery
  • Future Technologies

Lab Automation and Bioreactor Technologies


In vitro Test Systems

  • Standardized in vitro test systems
  • Disease models
  • hiPSC technologies

Preclinical and Clinical Development

  • Implants / GMP
  • Preclinical / GLP

Chair of Tissue
Engineering and
Regenerative Medicine

  • Development of supporting structures
  • Cell culture techniques

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Project TheraVision – Innovative therapy against cancer

In the "TheraVision" project, five Fraunhofer Institutes have set themselves the goal of establishing a widely applicable platform technology for an innovative, sustainable cancer therapy that combines cancer-killing viruses and immunotherapy. The activation of the immune system against the degenerated tumor cells is a novel promising therapeutic approach.

News and Events


Biofabrication meets Infection

PhD students of the SFB/TRR 225 Collaborative Research Centre “Biofabrication” and the GRK2157 "3D Infect" research group are organizing an amazing joint international symposium "Biofabrication meets Infection", which will take place on the 23 – 25. November 2022 at the Rudolf Virchow Center in Wuerzburg (Germany). Numerous high-profile speakers have already confirmed their participation. This international conference will focus primarily on topics of biofabrication and complex tissue models.
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CellME 2022

Empowering breakthroughs for life: At the CellME Forum, you can meet providers of advanced solutions for cell manufacturing technologies, gene- and cell-based therapies, and regenerative medicine, share expertise, and see research facilities in operation.
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The annual congress provides an opportunity to share scientific experiences on alternatives to the use of animals in the life sciences, to learn about EU 3Rs policy, and to discuss new approaches to implementing the 3Rs in academic education at the European and international levels.
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Tissue Engineering – a practical seminar on 3D cell culture

The Fraunhofer seminar on Tissue engineering will provide a compact review of the basics of tissue engineering – in terms of biology, bioprocessing and materials science. The two-day online seminar will also offer an insight into practical applications at Fraunhofer, ranging from personalized test systems to the development and approval of cell-based therapies.
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Project APRONA

Flexible robot-based platform for automated production of nanoparticles.

Your local contact

Marco Metzger

Contact Press / Media

PD Dr. Marco Metzger

Director TLC-RT

Fraunhofer Translational Center Regenerative Therapies TLC-RT
Röntgenring 11
97070 Würzburg, Germany

Phone +49 931 3186686

Florian Groeber-Becker

Contact Press / Media

Dr. Florian Groeber-Becker

Deputy Director of TLC-RT / Head of in vitro Test Systems

Translational Center Regenerative Therapies TLC-RT
Neunerplatz 2
97082 Würzburg, Germany

Phone +49 931 31-86669

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