Fraunhofer Translational Center Regenerative Therapies TLC-RT

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Lab Automation and Bioreactor Technologies

The incubator and bioreactor systems developed at TLC-RT have a modular structure and can be adjusted to a wide variety of culture conditions.

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The TLC-RT develops synthetic as well as bio-logically based materials, e. g. (μ- and nano-) particles, fibers, coatings for regenerative medicine, tissue engineering and diagnostics. One of the core tasks is to cover the entire value chain, starting from R&D-tasks over process up-scaling, pre-clinic evaluation to the clinical phases.

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Clinical Development

The production of novel drugs and medical devices is subject to high quality requirements. By fulfilling current regulatory guidelines, the TLC-RT ensures the highest level of patient safety for these new, innovative therapies.

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Test Systems and 3D Tissue Models

3D tissue models includes model systems of healthy and diseased organs to study pathogenic mechanisms and to test and evaluate new drugs. Picture shows a full skin model.

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Fraunhofer Translational Center Regenerative Therapies TLC-RT

The Fraunhofer Translational Center Regenerative Therapies TLC-RT develops new cell based tissue models and test systems, scalable manufacture processes, prototypes and biological vascularized implants. Therefore, besides accelerating cost efficient drug development, TLC-RT contributes to promoting the 3R principles.

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Fields of Activity and Teaching



  • Regenerative Biomaterials
  • In vitro and in vivo diagnostics
  • Drug Delivery
  • Future Technologies

Lab Automation and Bioreactor Technologies


In vitro Testsystems

  • Standardized in vitro test systems
  • Disease models
  • hiPSC technologies

Preclinical and Clinical Development

  • Implants / GMP
  • Preclinical / GLP

Chair of Tissue
Engineering and
Regenerative Medicine

  • Development of supporting structures
  • Cell culture techniques

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Project TheraVision – Innovative therapy against cancer

In the "TheraVision" project, five Fraunhofer Institutes have set themselves the goal of establishing a widely applicable platform technology for an innovative, sustainable cancer therapy that combines cancer-killing viruses and immunotherapy. The activation of the immune system against the degenerated tumor cells is a novel promising therapeutic approach.

News and Events


New ways to avoid animal testing –
Human 3D Tissue Models Conference in Würzburg

Around 60 international experts met on November 7 at the Fraunhofer Institute for Silicate Research ISC in Würzburg to report on the state of the art in the field of 3D tissue models and prevention of animal experiments in the development of pharmaceuticals and medical devices. The Forum MedTech Pharma and the Fraunhofer Translational Center for Regenerative Therapies TLC-RT had invited to the conference, which is scheduled to take place annually.
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Human 3D Tissue Models: 3R in the Light of Drug Development and MDR

At the conference, representatives of research institutes, clinics and industry will present novel human 3D tissue models and test systems, applied in pharma research and development as well as for medical device testing. Upcoming technologies such as Bio-Printing or Organ-on-a-Chip will also be demonstrated.
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Labvolution 2019

From 21 to 23 May Fraunhofer ISC will be exhibiting at Labvolution, Europe’s flagship fair for innovative lab equipment. At our booth there is shown a robot based unit, needed for the implementation for he project APRONA.
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German Biotech Days 2019

On April 9 - 10, the Fraunhofer ISC will participate at the German Biotech Days (DBT), the leading networking platform for the German biotech industry. Dr. Oliver Pullig will give a lecture in the slot "Biotech, Medtech und IT – Konvergenz oder Konkurrenz", which takes place on April 10, from 2.00 to 3.30 pm.
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Project APRONA

Flexible robot-based platform for automated production of nanoparticles.

Your local contact

Marco Metzger

Contact Press / Media

PD Dr. Marco Metzger

Director TLC-RT

Fraunhofer Translational Center Regenerative Therapies TLC-RT
Röntgenring 11
97070 Würzburg, Germany

Phone +49 931 3186686

Oliver Pullig

Contact Press / Media

PD Dr. Oliver Pullig

Deputy Director of TLC-RT / Head of Clinical Development

Translational Center Regenerative Therapies TLC-RT
Röntgenring 11
97070 Würzburg, Germany

Phone +49 931 31-83748