Fraunhofer Translational Center Regenerative Therapies TLC-RT

The Fraunhofer Translational Center Regenerative Therapies TLC-RT develops new cell based tissue models and test systems, scalable manufacture processes, prototypes and biological vascularized implants. Therefore, besides accelerating cost efficient drug development, TLC-RT contributes to promoting the 3R principles.

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Online Seminar Tissue Engineering 2022

On July 20 and 21, 2022, you will receive a comprehensive overview of the basics of tissue engineering and insights into practical applications.


Novel Nanoparticles for Biomedical Application

For a special issue of the MDPI Journal, guest editors Dr. Sofia Dembski and Dr. Jörn Probst are looking for thematically appropriate manuscripts.
Deadline: October 31, 2022


Nanoparticles meet

Quality assurance, cost savings, occupational safety are only three of many aspects achieved in the automated production of nanoparticles. A dual-arm robot interacts with the surrounding laboratory infrastructure 24/7.

Dr. Sofia Dembski provides information on the fascinating future of Lab 4.0 in a case study on the APRONA prototype plant.


Felix-Wankel-Award '21

Dr. Christian Lotz (Deputy Head of Department In Vitro Test Systems) receives this year's Felix Wankel Prize for the development of an in vitro eye irritation test.

The new method is expected to replace the Draize eye test after about 80 years and thus provide an alternative to previous animal testing.

Congratulations on this success!


Award winner at the Pitch Awards 2021

Sanjana Mathew won the 2nd place at the Pitch Awards 2021 of the stem cell network NRW.

Sanjana Mathew, PhD student in Dr. Antje Appelt-Menzel's team, used a bioreactor with dynamic flow, which enables the quality control of the barrier of blood-brain barrier models through online impedance measurement.


2nd place at the Hugo-Junkers-Preis 2020

As part of the research consortium HiPSTAR, Dr. Appelt-Menzel won the 2nd place at the Hugo-Junkers-Preis 2020 in the field of basic research.

The research team examines the dementia Alzheimer's desease and the role of the blood-brain barrier in its development and treatment. Novel therapies can be tested without animal experiments using in vitro models derived from patient-specific stem cells.

Fields of Activity and Teaching



  • Regenerative Biomaterials
  • In vitro and in vivo diagnostics
  • Drug Delivery
  • Future Technologies

Lab Automation and Bioreactor Technologies


In vitro Test Systems

  • Standardized in vitro test systems
  • Disease models
  • hiPSC technologies

Preclinical and Clinical Development

  • Implants / GMP
  • Preclinical / GLP

Chair of Tissue
Engineering and
Regenerative Medicine

  • Development of supporting structures
  • Cell culture techniques

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Project TheraVision – Innovative therapy against cancer

In the "TheraVision" project, five Fraunhofer Institutes have set themselves the goal of establishing a widely applicable platform technology for an innovative, sustainable cancer therapy that combines cancer-killing viruses and immunotherapy. The activation of the immune system against the degenerated tumor cells is a novel promising therapeutic approach.

News and Events


Tissue Engineering – a practical seminar on 3D cell culture

The Fraunhofer seminar on Tissue engineering will provide a compact review of the basics of tissue engineering – in terms of biology, bioprocessing and materials science. The two-day online seminar will also offer an insight into practical applications at Fraunhofer, ranging from personalized test systems to the development and approval of cell-based therapies.
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analytica 2022

At this year's analytica, we will present our developments in the area of "LAB 4.0 for Digital Life Science". In a live presentation, our research team will demonstrate the automated, non-invasive examination of tumor growth using tissue models of malignant melanomas. Our cell biological test system MediTOM as well as an automated image analysis (Image Analyzer) including digital evaluation, which transfers its data into a digital lab book, will be used.
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ISSCR 2022 Annual Meeting

Between June 15-18, 2022 the team from the Fraunhofer Project Center for Stem Cell Process Engineering SPT will present their innovative technologies and services in the field of induced pluripotent stem cells at the ‚ISSCR 2022 Annual Meeting‘ in San Francisco (booth 643), organized by the International Society for Stem Cell Research. There, the SPT offers solutions for upscaling validated bioprocesses for the production and preparation of high-grade stem cells and their derivatives, specifically adapting innovative materials, bioreactors, tissue engineering scaffolds and innovative, autonomous cell production and cryopreservation technologies.
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At ARABLAB 2021, Fraunhofer ISC will present technologies from the Center of Device Development CeDeD and the Translational Center for Regenerative Therapies TLC-RT in Hall 4, Booth 510: AQUAJUST® CAM for the adjustment of laboratory glasses and an INCUBATOR system for tissue engineering.
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Project APRONA

Flexible robot-based platform for automated production of nanoparticles.

Your local contact

Marco Metzger

Contact Press / Media

PD Dr. Marco Metzger

Director TLC-RT

Fraunhofer Translational Center Regenerative Therapies TLC-RT
Röntgenring 11
97070 Würzburg, Germany

Phone +49 931 3186686

Oliver Pullig

Contact Press / Media

PD Dr. Oliver Pullig

Deputy Director of TLC-RT / Head of Clinical Development

Translational Center Regenerative Therapies TLC-RT
Röntgenring 11
97070 Würzburg, Germany

Phone +49 931 31-83748