Fraunhofer Translational Center Regenerative Therapies TLC-RT

The Fraunhofer Translational Center Regenerative Therapies TLC-RT develops new cell based tissue models and test systems, scalable manufacture processes, prototypes and biological vascularized implants. Therefore, besides accelerating cost efficient drug development, TLC-RT contributes to promoting the 3R principles.

Read more ...


Nanoparticles meet

Quality assurance, cost savings, occupational safety are only three of many aspects achieved in the automated production of nanoparticles. A dual-arm robot interacts with the surrounding laboratory infrastructure 24/7.

Dr. Sofia Dembski provides information on the fascinating future of Lab 4.0 in a case study on the APRONA prototype plant.


Felix-Wankel-Award '21

Dr. Christian Lotz (Deputy Head of Department In Vitro Test Systems) receives this year's Felix Wankel Prize for the development of an in vitro eye irritation test.

The new method is expected to replace the Draize eye test after about 80 years and thus provide an alternative to previous animal testing.

Congratulations on this success!


Award winner at the Pitch Awards 2021

Sanjana Mathew won the 2nd place at the Pitch Awards 2021 of the stem cell network NRW.

Sanjana Mathew, PhD student in Dr. Antje Appelt-Menzel's team, used a bioreactor with dynamic flow, which enables the quality control of the barrier of blood-brain barrier models through online impedance measurement.


2nd place at the Hugo-Junkers-Preis 2020

As part of the research consortium HiPSTAR, Dr. Appelt-Menzel won the 2nd place at the Hugo-Junkers-Preis 2020 in the field of basic research.

The research team examines the dementia Alzheimer's desease and the role of the blood-brain barrier in its development and treatment. Novel therapies can be tested without animal experiments using in vitro models derived from patient-specific stem cells.


Partner for EU projects

Fraunhofer ISC has an excellent record of accomplishments in European collaboration and can build on a large international network of research partners from industry as well as research.


Research against the corona virus

Tissue models for rapid drug testing

Fields of Activity and Teaching



  • Regenerative Biomaterials
  • In vitro and in vivo diagnostics
  • Drug Delivery
  • Future Technologies

Lab Automation and Bioreactor Technologies


In vitro Test Systems

  • Standardized in vitro test systems
  • Disease models
  • hiPSC technologies

Preclinical and Clinical Development

  • Implants / GMP
  • Preclinical / GLP

Chair of Tissue
Engineering and
Regenerative Medicine

  • Development of supporting structures
  • Cell culture techniques

Contact or callback?


Contact us today without any


Project TheraVision – Innovative therapy against cancer

In the "TheraVision" project, five Fraunhofer Institutes have set themselves the goal of establishing a widely applicable platform technology for an innovative, sustainable cancer therapy that combines cancer-killing viruses and immunotherapy. The activation of the immune system against the degenerated tumor cells is a novel promising therapeutic approach.

News and Events



At ARABLAB 2021, Fraunhofer ISC will present technologies from the Center of Device Development CeDeD and the Translational Center for Regenerative Therapies TLC-RT in Hall 4, Booth 510: AQUAJUST® CAM for the adjustment of laboratory glasses and an INCUBATOR system for tissue engineering.
Read more


Online Seminar: Essentials of 3D Tissue Engineering 2021

The course offering "Tissue Engineering - Essentials of 3D Tissue Engineering" provides a comprehensive overview of the biological and material science fundamentals of tissue engineering in two half-course days and provides insights into practical applications, from personalized test systems to the development and approval of cell-based therapies.
Read more

Project APRONA

Flexible robot-based platform for automated production of nanoparticles.

Your local contact

Marco Metzger

Contact Press / Media

PD Dr. Marco Metzger

Director TLC-RT

Fraunhofer Translational Center Regenerative Therapies TLC-RT
Röntgenring 11
97070 Würzburg, Germany

Phone +49 931 3186686

Oliver Pullig

Contact Press / Media

PD Dr. Oliver Pullig

Deputy Director of TLC-RT / Head of Clinical Development

Translational Center Regenerative Therapies TLC-RT
Röntgenring 11
97070 Würzburg, Germany

Phone +49 931 31-83748