News, projects and events

On this page you will find information from the TLC Würzburg on current topics, on our research projects as well as all important dates such as workshops, online seminars and trade fair appearances.

 

Press Release / 29.7.2022

Awarded!

DFG Animal Welfare Prize for the Fraunhofer Translational Center for Regenerative Therapies

For its application, the Würzburg Initiative 3R (WI3R) had presented the development and application of six in vitro models of the barrier organs skin, cornea, intestine, blood-brain barrier and lung as well as for solid tumors, which serve to "replace" the 3R concept.

 

Felix-Wankel-Award '21

Dr. Christian Lotz (Deputy Head of Department In Vitro Test Systems) receives this year's Felix Wankel Prize for the development of an in vitro eye irritation test.

The new method is expected to replace the Draize eye test after about 80 years and thus provide an alternative to previous animal testing.


Congratulations on this success!

 

3D Bioprinting Technology

for automatized and standardized fabrication of complex living tissues

 

Press Release / 9.8.2022

Antiviral effect of plant extracts

Proof with in vitro cell cultures successful

 

Press Release / 19.11.2020

Project launch »ImAi«

New test procedure to replace worldwide standard animal testing - project launched

 

Project APRONA

Flexible robot-based platform for automated nanoparticle production.

Dates and events

San Francisco, USA / June 15, 2022 - June 18, 2022

ISSCR 2022 Annual Meeting

Between June 15-18, 2022 the team from the Fraunhofer Project Center for Stem Cell Process Engineering SPT will present their innovative technologies and services in the field of induced pluripotent stem cells at the ‚ISSCR 2022 Annual Meeting‘ in San Francisco (booth 643), organized by the International Society for Stem Cell Research. There, the SPT offers solutions for upscaling validated bioprocesses for the production and preparation of high-grade stem cells and their derivatives, specifically adapting innovative materials, bioreactors, tissue engineering scaffolds and innovative, autonomous cell production and cryopreservation technologies.

Messe München / June 21, 2022 - June 24, 2022

analytica 2022

At this year's analytica, we will present our developments in the area of "LAB 4.0 for Digital Life Science". In a live presentation, our research team will demonstrate the automated, non-invasive examination of tumor growth using tissue models of malignant melanomas. Our cell biological test system MediTOM as well as an automated image analysis (Image Analyzer) including digital evaluation, which transfers its data into a digital lab book, will be used.

Online / July 20, 2022 - July 21, 2022, 09:00 - 17:00 Uhr

Online Seminar Tissue Engineering
»Basics of 3D cell culture«

The Fraunhofer seminar on Tissue engineering will provide a compact review of the basics of tissue engineering – in terms of biology, bioprocessing and materials science. The two-day online seminar will also offer an insight into practical applications at Fraunhofer, ranging from personalized test systems to the development and approval of cell-based therapies.

JKU MED Campus Linz + Online / September 26, 2022 - September 28, 2022

EUSAAT Congress 2022

The annual congress provides an opportunity to share scientific experiences on alternatives to the use of animals in the life sciences, to learn about EU 3Rs policy, and to discuss new approaches to implementing the 3Rs in academic education at the European and international levels.

12489 Berlin / October 18, 2022 - October 19, 2022, 9:00 - 18:00

CellME 2022

Empowering breakthroughs for life: At the CellME Forum, you can meet providers of advanced solutions for cell manufacturing technologies, gene- and cell-based therapies, and regenerative medicine, share expertise, and see research facilities in operation.

Rudolf Virchow Center, Wuerzburg / November 23, 2022 - November 25, 2022

»Biofabrication meets Infection«

PhD students of the SFB/TRR 225 Collaborative Research Centre “Biofabrication” and the GRK2157 "3D Infect" research group are organizing an amazing joint international symposium "Biofabrication meets Infection", which will take place on the 23 – 25. November 2022 at the Rudolf Virchow Center in Wuerzburg (Germany). Numerous high-profile speakers have already confirmed their participation. This international conference will focus primarily on topics of biofabrication and complex tissue models.

Nanoparticles meet Automation

New concepts for automated processes in materials production and testing

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Biomaterials for Organ and Tissue Regeneration –
New Technologies and Future Prospects

Book-Cover Biomaterials For Organ And Tissue Regeneration
© Elsevier
Paperback ISBN: 9780081029060
eBook ISBN: 9780081029077

The book describes biomaterial-related technologies, providing comprehensive fundamentals on the properties and use of biomaterials in the context of tissue regeneration and in vitro modeling of organ systems.

By way of introduction, properties and forms of novel biomaterials are described and an overview of so-called off-shoot technologies such as biorobotics, bioinks or bioprinting is given. In addition to a summary of physico-chemical properties, methods used to analyze biostructural characterization and surface functionalization of biomaterials will be addressed.
In addition, properties of modern cell sources such as stem cells and immune cells relevant to regenerative medicine are described. In addition, fundamentals of cellular communication with biomaterials will also be addressed. Subsequently, current organ-specific application areas of biomaterials will be explained. These include, for example, cardiovascular and pancreatic tissue engineering, as well as in vitro replication of the blood-brain barrier, lung, kidney or bladder. Fraunhofer ISC has made a further contribution in this context with the article "Bioartificial gut".

The book concludes with a summary of novel technologies, especially with regard to biomaterials and their relevance for tissue and organ regeneration. Besides nanomaterials and hydrogels, biomaterials and their application in the context of microfluidics, for organ-chip systems or their integration in dynamic bioreactors are discussed.

Three-dimensional airway tissue models based on human primary airway epithelial cells.

Heatmap 3D tissue model
Lodes N, Seidensticker K, Perniss A, Nietzer S, Oberwinkler H, May T, Walles T, Hebestreit H, Hackenberg S, Steinke M. »Investigation on Ciliary Functionality of Different Airway Epithelial Cell Lines in Three-Dimensional Cell Culture«. Tissue Eng Part A. 2019 Dec 27. doi: 10.1089/ten.TEA

A team of researchers from the Fraunhofer TLZ and the University Hospital Würzburg, the Justus Liebig University Giessen, the Otto von Guericke University Magdeburg and the Inscreenex GmbH Braunschweig has compared three-dimensional (3D) airway tissue models based on human primary airway epithelial cells (hAEC) or corresponding cell lines and analyzed in particular the functionality of the cilia (kinocilia).
The aim of the work is to enable the future investigation of ciliopathies, i.e. disorders of the activity of the cilia in the respiratory tract, using human 3D tissue models. To this end, four different human respiratory cell lines were cultured with human primary airway fibroblasts at the medium-air interface and their morphology and cilia beat were analyzed. The study results show that the available cell lines are not suitable for scientific questions that require functional kinocilia to answer. According to current knowledge, 3D tissue models based on hAEC have the highest in vitro - in vivo correlation.