Test Systems and 3D Tissue Models

Preclinical risk and efficacy testing and the development of new products in the chemical industry are currently dependent on animal experiments. Fraunhofer ISC develops ethically accepted 3D Tissue Models which are often more predictive compared to animal testings. These models are very close to morphological and functional properties of human tissues. In addition, we are developing new technologies such as non-invasive assessment methods or automated tissue production to improve the quality and availability of the tissues. By creating new tissue models and technologies innovative test procedures can be established to ensure the effectiveness and safety of new products.


Current Foci

  • Standardized in vitro test systems
  • Health and disease models
  • Custom development of test procedures based on in vitro tissue models



  • Primary cell banks and hiPSC technologies sourcing the growth of human tissue models
  • Organ-on-a-chip systems
  • BioVaSc-TERM: Biological platform for the production of vascularized tissue models


Available 3D Tissue Models

  • Skin (epidermal model (RHE), full thickness, vascularized)
  • Cutaneous wounds
  • Cornea
  • hiPSC based blood-brain barrier
  • Intestine
  • Airways
  • Colon cancer
  • Lung carcinoma
  • Mammae carcinoma
  • Malignant melanoma



  • Risk assessment of substances
  • Development of automized healthy and diseased tissue models
  • Gene expression and histomorphological analyses
  • Infection studies
  • Analyses of cell-cell and cell-material interactions