Current Projects and News

Current Projects

  • Development of an impedance spectrometric method for assessing cell growth and protein / blood cell occupancy of membranes in hollow-fiber bioreactors and dialyzers – Support initiative “Medizintechnik Bayern” (Medical technology Bavaria)
  • Flexible robot-based platform for automated production of nanoparticles (German press release)
  • In vitro test procedures to evaluate the effectiveness of immunological therapies for malignant melanoma (Press release)
  • Cryopreservation of three-dimensional cell cultures
  • Nanoparticle-based contrast agent for multimodal in vivo diagnostics
  • Tumor diagnostics for individualized therapy

 

Finalized projects:

Biomaterials for Organ and Tissue Regeneration –
New Technologies and Future Prospects

Book-Cover Biomaterials For Organ And Tissue Regeneration
© Elsevier
Paperback ISBN: 9780081029060
eBook ISBN: 9780081029077

The book describes biomaterials-related technologies, providing comprehensive information on the properties and use of biomaterials in tissue regeneration and in vitro modelling of organs.

In the introduction, properties and forms of novel biomaterials are described and off-shoot technologies such as Biorobotics, Bioinks or Bioprinting are discussed. In addition to a summary of physico-chemical properties, methods used for the analysis of biostructural characterization and surface functionalization of biomaterials are reviewed. Furthermore, properties of modern cell sources such as stem cells and immune cells with relevance for regenerative medicine are described. In addition, basic principles of cellular communication with biomaterials are addressed. Following, current organ-specific application areas of biomaterials are summarized. These include cardiovascular and pancreatic tissue engineering approaches as well as in vitro modelling of the blood-brain barrier, lung, kidney or bladder. With the article "Bioartificial good", the Fraunhofer ISC has made a further contribution in this context.

The book concludes with a summary of novel technologies, especially with regard to biomaterials and their significance for tissue and organ regeneration. Besides nanomaterials and hydrogels, focus is on biomaterials and their application in microfluidics, in organ-on-a-chip systems or their integration into dynamic bioreactors.

Three-dimensional airway tissue models based on human primary airway epithelial cells

Heatmap 3D tissue model
Lodes N, Seidensticker K, Perniss A, Nietzer S, Oberwinkler H, May T, Walles T, Hebestreit H, Hackenberg S, Steinke M. »Investigation on Ciliary Functionality of Different Airway Epithelial Cell Lines in Three-Dimensional Cell Culture«. Tissue Eng Part A. 2019 Dec 27. doi: 10.1089/ten.TEA

A team of researchers from the Fraunhofer TLZ as well as the University Clinic Würzburg, the Justus Liebig University Gießen, the Otto von Guericke University Magdeburg and the Inscreenex GmbH Braunschweig compared three-dimensional (3D) airway tissue models based on human primary airway epithelial cells (hAEC) and corresponding cell lines and analyzed in particular the functionality of the cilia (cinemacillus).
The aim of the work is to enable the future investigation of ciliopathies, i.e. disorders of the activity of the cilia in the airways, using human 3D tissue models. For this purpose, four different human respiratory cell lines with human primary respiratory fibroblasts at the medium-air interface were cultivated and their morphology as well as the cilial beat were analysed. The results show that the available cell lines are not suitable for scientific questions, which require functional kinocilia. According to current knowledge, 3D tissue models based on hAEC have the highest in vitro - in vivo - correlation.

 

Research against the corona virus - tissue models for rapid drug testing (Press Release)

Press Releases

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  • Collagen membrane seeded with cartilage cells
    © Fraunhofer ISC

    As a pioneer in applied research, the Fraunhofer-Gesellschaft brings together the expertise of 23 separate Fraunhofer facilities to develop new development and production technologies for innovative cell and gene therapeutics, as well as vaccines, in the “Production for Intelligent Medicine” innovation cluster. As a first step of the project, a concept for a modular pilot plant for the automatic production of these therapeutics is to be developed combining both Industry 4.0 and Health 4.0.

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  • The pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is placing unprecedented restrictions on public life and economy. The global research efforts to fill the knowledge gaps regarding the new pathogen and to develop effective therapies are correspondingly large. In Wuerzburg, too, researchers from the Fraunhofer Translational Center for Regenerative Therapies are working together with the virologist Prof. Dr. Bodem from the University of Wuerzburg to identify active substances against the virus.

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  • Around 60 international experts met on November 7 at the Fraunhofer Institute for Silicate Research ISC in Würzburg to report on the state of the art in the field of 3D tissue models and prevention of animal experiments in the development of pharmaceuticals and medical devices. The Forum MedTech Pharma and the Fraunhofer Translational Center for Regenerative Therapies TLC-RT had invited to the conference, which is scheduled to take place annually.

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  • The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

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Events

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  • Online /  October 26, 2020 - October 29, 2020

    Fraunhofer Solution Days 2020

    As part of the project “Go Beyond 4.0”, Fraunhofer ISC is participating in the digital Fraunhofer event, the Solution Days, on October 26, 2020. You can look forward to the latest technology highlights, workshops and live chats with our experts. We are looking forward to your visit on our digital booth.

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